increased pancreatic ductal adenocarcinoma incidence_Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<tm2Tyj>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>

http://metadb.riken.jp/0009151I129P2OlaHsd129S4SvJaeKrastm4TyjKrasTrp53tm1BrnTrp53tm2TyjPtf1atm1creHnakPtf1aTrp53tm2TyjPtf1atm1creHnakKrasKrastm4TyjTrp53tm1BrnPtf1a

increased pancreatic ductal adenocarcinoma incidence_Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<tm2Tyj>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• pancreas specific transcription factor, 1a
  http://metadb.riken.jp/db/mgi_rdf/MGI:1328312
• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<tm2Tyj>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<tm2Tyj>|Ptf1a<tm1(cre)Hnak>|Kras<+>|Kras<tm4Tyj>|Trp53<tm1Brn>|Ptf1a<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S4/SvJae

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased pancreatic ductal adenocarcinoma incidence
  http://purl.obolibrary.org/obo/MP_0009151

文献

http://purl.org/net/cito/citesAsAuthority

• Stefan. Eser, et.al., Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer., Cancer cell, 2013, 23
  http://rdf.ncbi.nlm.nih.gov/pubmed/23453624