increased pancreatic ductal adenocarcinoma incidence_Brca2<tm1Brn>/Brca2<tm1Cam>,Kras<tm4Tyj>/Kras<+>,Trp53<tm3Tyj>/Trp53<+>,Tg(Pdx1-cre)6Tuv/0

http://metadb.riken.jp/0009151I129P2OlaHsd129SSvEv129S4SvJaeC57BL6FVBNBrca2tm1BrnBrca2tm1CamKrastm4TyjKrasTrp53tm3TyjTrp53TgPdx1cre6Tuv0Trp53Brca2tm1CamBrca2tm1BrnTgPdx1cre6TuvKrastm4TyjKrasTrp53tm3Tyj

increased pancreatic ductal adenocarcinoma incidence_Brca2<tm1Brn>/Brca2<tm1Cam>,Kras<tm4Tyj>/Kras<+>,Trp53<tm3Tyj>/Trp53<+>,Tg(Pdx1-cre)6Tuv/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• breast cancer 2, early onset
  http://metadb.riken.jp/db/mgi_rdf/MGI:109337
• transgene insertion 6, David A Tuveson
  http://metadb.riken.jp/db/mgi_rdf/MGI:5437123
• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Brca2<tm1Brn>/Brca2<tm1Cam>,Kras<tm4Tyj>/Kras<+>,Trp53<tm3Tyj>/Trp53<+>,Tg(Pdx1-cre)6Tuv/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<+>|Brca2<tm1Cam>|Brca2<tm1Brn>|Tg(Pdx1-cre)6Tuv|Kras<tm4Tyj>|Kras<+>|Trp53<tm3Tyj>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased pancreatic ductal adenocarcinoma incidence
  http://purl.obolibrary.org/obo/MP_0009151

文献

http://purl.org/net/cito/citesAsAuthority

• Ferdinandos. Skoulidis, et.al., Germline Brca2 heterozygosity promotes Kras(G12D) -driven carcinogenesis in a murine model of familial pancreatic cancer., Cancer cell, 2010, 18
  http://rdf.ncbi.nlm.nih.gov/pubmed/21056012