Ferdinandos. Skoulidis, et.al., Germline Brca2 heterozygosity promotes Kras(G12D) -driven carcinogenesis in a murine model of familial pancreatic cancer., Cancer cell, 2010, 18

http://rdf.ncbi.nlm.nih.gov/pubmed/21056012

Ferdinandos. Skoulidis, et.al., Germline Brca2 heterozygosity promotes Kras(G12D) -driven carcinogenesis in a murine model of familial pancreatic cancer., Cancer cell, 2010, 18

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• premature death_Brca2<tm1Cam>/Brca2<tm1Brn>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0002083I129P2OlaHsd129SSvEvC57BL6FVBNBrca2tm1CamBrca2tm1BrnTgPdx1cre6Tuv0TgPdx1cre6TuvBrca2tm1CamBrca2tm1Brn
• increased pancreatic ductal adenocarcinoma incidence_Kras<tm4Tyj>/Kras<+>,Tg(Pdx1-cre)6Tuv/0,Trp53<tm3Tyj>/Trp53<+>
  http://metadb.riken.jp/0009151I129S4SvJaeC57BL6FVBNKrastm4TyjKrasTgPdx1cre6Tuv0Trp53tm3TyjTrp53TgPdx1cre6TuvKrastm4TyjKrasTrp53tm3TyjTrp53
• increased pancreatic acinar cell carcinoma incidence_Brca2<tm1Brn>/Brca2<tm1Cam>,Kras<tm4Tyj>/Kras<+>,Trp53<tm3Tyj>/Trp53<+>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0008780I129P2OlaHsd129SSvEv129S4SvJaeC57BL6FVBNBrca2tm1BrnBrca2tm1CamKrastm4TyjKrasTrp53tm3TyjTrp53TgPdx1cre6Tuv0Trp53Brca2tm1CamBrca2tm1BrnTgPdx1cre6TuvKrastm4TyjKrasTrp53tm3Tyj
• exocrine pancreatic insufficiency_Brca2<tm1Cam>/Brca2<tm1Brn>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0003335I129P2OlaHsd129SSvEvC57BL6FVBNBrca2tm1CamBrca2tm1BrnTgPdx1cre6Tuv0TgPdx1cre6TuvBrca2tm1CamBrca2tm1Brn
• increased malignant tumor incidence_Brca2<tm1Cam>/Brca2<tm1Brn>,Tg(Pdx1-cre)6Tuv/0,Trp53<tm3Tyj>/Trp53<+>
  http://metadb.riken.jp/0002018I129P2OlaHsd129SSvEv129S4SvJaeC57BL6FVBNBrca2tm1CamBrca2tm1BrnTgPdx1cre6Tuv0Trp53tm3TyjTrp53Brca2tm1BrnTrp53Brca2tm1CamTrp53tm3TyjTgPdx1cre6Tuv
• premature death_Brca2<tm1Cam>/Brca2<+>,Kras<tm4Tyj>/Kras<+>,Trp53<tm3Tyj>/Trp53<+>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0002083I129SSvEv129S4SvJaeC57BL6FVBNBrca2tm1CamBrca2Krastm4TyjKrasTrp53tm3TyjTrp53TgPdx1cre6Tuv0Trp53Brca2tm1CamTrp53tm3TyjKrastm4TyjTgPdx1cre6TuvBrca2Kras
• premature death_Brca2<tm1Cam>/Brca2<+>,Kras<tm4Tyj>/Kras<+>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0002083I129SSvEv129S4SvJaeC57BL6FVBNBrca2tm1CamBrca2Krastm4TyjKrasTgPdx1cre6Tuv0Brca2tm1CamKrastm4TyjTgPdx1cre6TuvKrasBrca2
• increased pancreatic ductal adenocarcinoma incidence_Brca2<tm1Cam>/Brca2<+>,Kras<tm4Tyj>/Kras<+>,Trp53<tm3Tyj>/Trp53<+>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0009151I129SSvEv129S4SvJaeC57BL6FVBNBrca2tm1CamBrca2Krastm4TyjKrasTrp53tm3TyjTrp53TgPdx1cre6Tuv0Trp53Brca2tm1CamTrp53tm3TyjKrastm4TyjTgPdx1cre6TuvBrca2Kras
• increased pancreatic ductal adenocarcinoma incidence_Brca2<tm1Cam>/Brca2<+>,Kras<tm4Tyj>/Kras<+>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0009151I129SSvEv129S4SvJaeC57BL6FVBNBrca2tm1CamBrca2Krastm4TyjKrasTgPdx1cre6Tuv0Brca2tm1CamKrastm4TyjTgPdx1cre6TuvKrasBrca2
• premature death_Brca2<tm1Cam>/Brca2<tm1Brn>,Kras<tm4Tyj>/Kras<+>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0002083I129P2OlaHsd129SSvEv129S4SvJaeC57BL6FVBNBrca2tm1CamBrca2tm1BrnKrastm4TyjKrasTgPdx1cre6Tuv0Brca2tm1BrnBrca2tm1CamTgPdx1cre6TuvKrastm4TyjKras
• premature death_Brca2<tm1Brn>/Brca2<tm1Cam>,Kras<tm4Tyj>/Kras<+>,Trp53<tm3Tyj>/Trp53<+>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0002083I129P2OlaHsd129SSvEv129S4SvJaeC57BL6FVBNBrca2tm1BrnBrca2tm1CamKrastm4TyjKrasTrp53tm3TyjTrp53TgPdx1cre6Tuv0Trp53Brca2tm1CamBrca2tm1BrnTgPdx1cre6TuvKrastm4TyjKrasTrp53tm3Tyj
• increased pancreatic ductal adenocarcinoma incidence_Brca2<tm1Cam>/Brca2<tm1Brn>,Kras<tm4Tyj>/Kras<+>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0009151I129P2OlaHsd129SSvEv129S4SvJaeC57BL6FVBNBrca2tm1CamBrca2tm1BrnKrastm4TyjKrasTgPdx1cre6Tuv0Brca2tm1BrnBrca2tm1CamTgPdx1cre6TuvKrastm4TyjKras
• increased pancreas apoptosis_Brca2<tm1Cam>/Brca2<tm1Brn>,Kras<tm4Tyj>/Kras<+>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0013220I129P2OlaHsd129SSvEv129S4SvJaeC57BL6FVBNBrca2tm1CamBrca2tm1BrnKrastm4TyjKrasTgPdx1cre6Tuv0Brca2tm1BrnBrca2tm1CamTgPdx1cre6TuvKrastm4TyjKras
• exocrine pancreatic insufficiency_Brca2<tm1Cam>/Brca2<tm1Brn>,Kras<tm4Tyj>/Kras<+>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0003335I129P2OlaHsd129SSvEv129S4SvJaeC57BL6FVBNBrca2tm1CamBrca2tm1BrnKrastm4TyjKrasTgPdx1cre6Tuv0Brca2tm1BrnBrca2tm1CamTgPdx1cre6TuvKrastm4TyjKras
• exocrine pancreatic insufficiency_Brca2<tm1Cam>/Brca2<tm1Brn>,Tg(Pdx1-cre)6Tuv/0,Trp53<tm3Tyj>/Trp53<+>
  http://metadb.riken.jp/0003335I129P2OlaHsd129SSvEv129S4SvJaeC57BL6FVBNBrca2tm1CamBrca2tm1BrnTgPdx1cre6Tuv0Trp53tm3TyjTrp53Brca2tm1BrnTrp53Brca2tm1CamTrp53tm3TyjTgPdx1cre6Tuv
• premature death_Brca2<tm1Cam>/Brca2<tm1Brn>,Tg(Pdx1-cre)6Tuv/0,Trp53<tm3Tyj>/Trp53<+>
  http://metadb.riken.jp/0002083I129P2OlaHsd129SSvEv129S4SvJaeC57BL6FVBNBrca2tm1CamBrca2tm1BrnTgPdx1cre6Tuv0Trp53tm3TyjTrp53Brca2tm1BrnTrp53Brca2tm1CamTrp53tm3TyjTgPdx1cre6Tuv
• increased sarcoma incidence_Brca2<tm1Cam>/Brca2<tm1Brn>,Tg(Pdx1-cre)6Tuv/0,Trp53<tm3Tyj>/Trp53<+>
  http://metadb.riken.jp/0002032I129P2OlaHsd129SSvEv129S4SvJaeC57BL6FVBNBrca2tm1CamBrca2tm1BrnTgPdx1cre6Tuv0Trp53tm3TyjTrp53Brca2tm1BrnTrp53Brca2tm1CamTrp53tm3TyjTgPdx1cre6Tuv
• increased pancreatic ductal adenocarcinoma incidence_Brca2<tm1Brn>/Brca2<tm1Cam>,Kras<tm4Tyj>/Kras<+>,Trp53<tm3Tyj>/Trp53<+>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0009151I129P2OlaHsd129SSvEv129S4SvJaeC57BL6FVBNBrca2tm1BrnBrca2tm1CamKrastm4TyjKrasTrp53tm3TyjTrp53TgPdx1cre6Tuv0Trp53Brca2tm1CamBrca2tm1BrnTgPdx1cre6TuvKrastm4TyjKrasTrp53tm3Tyj
• premature death_Kras<tm4Tyj>/Kras<+>,Tg(Pdx1-cre)6Tuv/0,Trp53<tm3Tyj>/Trp53<+>
  http://metadb.riken.jp/0002083I129S4SvJaeC57BL6FVBNKrastm4TyjKrasTgPdx1cre6Tuv0Trp53tm3TyjTrp53TgPdx1cre6TuvKrastm4TyjKrasTrp53tm3TyjTrp53

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD04972
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD04972
• CD01388
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD01388