increased pancreatic ductal adenocarcinoma incidence_Cdkn2a<tm4Rdp>/Cdkn2a<+>,Kras<tm4Tyj>/Kras<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>

http://metadb.riken.jp/0009151I129S1Sv129S4SvJae129X1SvJCdkn2atm4RdpCdkn2aKrastm4TyjKrasPtf1atm11creCvwPtf1aCdkn2aPtf1atm11creCvwCdkn2atm4RdpPtf1aKrasKrastm4Tyj

increased pancreatic ductal adenocarcinoma incidence_Cdkn2a<tm4Rdp>/Cdkn2a<+>,Kras<tm4Tyj>/Kras<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• cyclin-dependent kinase inhibitor 2A
  http://metadb.riken.jp/db/mgi_rdf/MGI:104738
• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680
• pancreas specific transcription factor, 1a
  http://metadb.riken.jp/db/mgi_rdf/MGI:1328312

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cdkn2a<tm4Rdp>/Cdkn2a<+>,Kras<tm4Tyj>/Kras<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Cdkn2a<+>|Ptf1a<tm1.1(cre)Cvw>|Cdkn2a<tm4Rdp>|Ptf1a<+>|Kras<+>|Kras<tm4Tyj>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased pancreatic ductal adenocarcinoma incidence
  http://purl.obolibrary.org/obo/MP_0009151

文献

http://purl.org/net/cito/citesAsAuthority

• Nabeel. Bardeesy, et.al., Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer., Genes & development, 2006, 20
  http://rdf.ncbi.nlm.nih.gov/pubmed/17114584