increased pancreatic ductal adenocarcinoma incidence_Kras<tm4Tyj>/Kras<+>,Trp53<tm2Tyj>/Trp53<+>,Tg(Pdx1-cre)6Tuv/0

http://metadb.riken.jp/0009151I129S4SvJaeC57BL6FVBNKrastm4TyjKrasTrp53tm2TyjTrp53TgPdx1cre6Tuv0KrasKrastm4TyjTgPdx1cre6TuvTrp53tm2TyjTrp53

increased pancreatic ductal adenocarcinoma incidence_Kras<tm4Tyj>/Kras<+>,Trp53<tm2Tyj>/Trp53<+>,Tg(Pdx1-cre)6Tuv/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• transgene insertion 6, David A Tuveson
  http://metadb.riken.jp/db/mgi_rdf/MGI:5437123

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Kras<tm4Tyj>/Kras<+>,Trp53<tm2Tyj>/Trp53<+>,Tg(Pdx1-cre)6Tuv/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Kras<+>|Kras<tm4Tyj>|Tg(Pdx1-cre)6Tuv|Trp53<tm2Tyj>|Trp53<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased pancreatic ductal adenocarcinoma incidence
  http://purl.obolibrary.org/obo/MP_0009151

文献

http://purl.org/net/cito/citesAsAuthority

• Sunil R. Hingorani, et.al., Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice., Cancer cell, 2005, 7
  http://rdf.ncbi.nlm.nih.gov/pubmed/15894267