increased pancreatic intraepithelial neoplasia incidence_Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(tetO-Kras2)12Hev/0,Trp53<tm1Tyj>/Trp53<+>

http://metadb.riken.jp/0009152I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNGtROSA26Sortm1rtTAEGFPNagyGtROSA26SorPtf1atm11creCvwPtf1aTgtetOKras212Hev0Trp53tm1TyjTrp53Ptf1aGtROSA26SorTrp53tm1TyjTrp53Ptf1atm11creCvwGtROSA26Sortm1rtTAEGFPNagyTgtetOKras212Hev

increased pancreatic intraepithelial neoplasia incidence_Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(tetO-Kras2)12Hev/0,Trp53<tm1Tyj>/Trp53<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• transgene insertion 12, Harold E Varmus
  http://metadb.riken.jp/db/mgi_rdf/MGI:2179991
• pancreas specific transcription factor, 1a
  http://metadb.riken.jp/db/mgi_rdf/MGI:1328312
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(tetO-Kras2)12Hev/0,Trp53<tm1Tyj>/Trp53<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Ptf1a<+>|Gt(ROSA)26Sor<+>|Trp53<tm1Tyj>|Trp53<+>|Ptf1a<tm1.1(cre)Cvw>|Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>|Tg(tetO-Kras2)12Hev

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased pancreatic intraepithelial neoplasia incidence
  http://purl.obolibrary.org/obo/MP_0009152

文献

http://purl.org/net/cito/citesAsAuthority

• Meredith A. Collins, et.al., Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice., The Journal of clinical investigation, 2012, 122
  http://rdf.ncbi.nlm.nih.gov/pubmed/22232209