increased pancreatic intraepithelial neoplasia incidence_Kras<tm4Tyj>/Kras<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>

http://metadb.riken.jp/0009152I129S1Sv129S4SvJae129X1SvJC57BL6DBA2Krastm4TyjKrasPtf1atm11creCvwPtf1aPtf1atm11creCvwPtf1aKrasKrastm4Tyj

increased pancreatic intraepithelial neoplasia incidence_Kras<tm4Tyj>/Kras<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680
• pancreas specific transcription factor, 1a
  http://metadb.riken.jp/db/mgi_rdf/MGI:1328312

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Kras<tm4Tyj>/Kras<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Ptf1a<tm1.1(cre)Cvw>|Ptf1a<+>|Kras<+>|Kras<tm4Tyj>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased pancreatic intraepithelial neoplasia incidence
  http://purl.obolibrary.org/obo/MP_0009152

文献

http://purl.org/net/cito/citesAsAuthority

• Hideaki. Ijichi, et.al., Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression., Genes & development, 2006, 20
  http://rdf.ncbi.nlm.nih.gov/pubmed/17114585