Hideaki. Ijichi, et.al., Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression., Genes & development, 2006, 20

http://rdf.ncbi.nlm.nih.gov/pubmed/17114585

Hideaki. Ijichi, et.al., Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression., Genes & development, 2006, 20

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• jaundice_Kras<tm4Tyj>/Kras<+>,Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0000611I129SSv129X1SvJC57BL6DBA2Krastm4TyjKrasTgfbr2tm12HlmTgfbr2tm12HlmPtf1atm11creCvwPtf1aKrasTgfbr2tm12HlmKrastm4TyjPtf1aPtf1atm11creCvw
• abnormal pancreas development_Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>
  http://metadb.riken.jp/0003934I129S1Sv129S6SvEvTac129X1SvJC57BL6DBA2Ptf1atm11creCvwPtf1aTgfbr2tm12HlmTgfbr2tm12HlmPtf1atm11creCvwTgfbr2tm12HlmPtf1a
• abnormal duodenum morphology_Kras<tm4Tyj>/Kras<+>,Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0003271I129SSv129X1SvJC57BL6DBA2Krastm4TyjKrasTgfbr2tm12HlmTgfbr2tm12HlmPtf1atm11creCvwPtf1aKrasTgfbr2tm12HlmKrastm4TyjPtf1aPtf1atm11creCvw
• increased pancreas tumor incidence_Kras<tm4Tyj>/Kras<+>,Tgfbr2<tm1.2Hlm>/Tgfbr2<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0009153I129SSv129X1SvJC57BL6DBA2Krastm4TyjKrasTgfbr2tm12HlmTgfbr2Ptf1atm11creCvwPtf1aPtf1atm11creCvwKrasKrastm4TyjTgfbr2tm12HlmTgfbr2Ptf1a
• increased pancreatic intraepithelial neoplasia incidence_Kras<tm4Tyj>/Kras<+>,Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0009152I129SSv129X1SvJC57BL6DBA2Krastm4TyjKrasTgfbr2tm12HlmTgfbr2tm12HlmPtf1atm11creCvwPtf1aKrasTgfbr2tm12HlmKrastm4TyjPtf1aPtf1atm11creCvw
• increased metastatic potential_Kras<tm4Tyj>/Kras<+>,Tgfbr2<tm1.2Hlm>/Tgfbr2<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0001272I129SSv129X1SvJC57BL6DBA2Krastm4TyjKrasTgfbr2tm12HlmTgfbr2Ptf1atm11creCvwPtf1aPtf1atm11creCvwKrasKrastm4TyjTgfbr2tm12HlmTgfbr2Ptf1a
• enlarged spleen_Kras<tm4Tyj>/Kras<+>,Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0000691I129SSv129X1SvJC57BL6DBA2Krastm4TyjKrasTgfbr2tm12HlmTgfbr2tm12HlmPtf1atm11creCvwPtf1aKrasTgfbr2tm12HlmKrastm4TyjPtf1aPtf1atm11creCvw
• hepatic necrosis_Kras<tm4Tyj>/Kras<+>,Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0001654I129SSv129X1SvJC57BL6DBA2Krastm4TyjKrasTgfbr2tm12HlmTgfbr2tm12HlmPtf1atm11creCvwPtf1aKrasTgfbr2tm12HlmKrastm4TyjPtf1aPtf1atm11creCvw
• increased pancreatic intraepithelial neoplasia incidence_Kras<tm4Tyj>/Kras<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0009152I129S1Sv129S4SvJae129X1SvJC57BL6DBA2Krastm4TyjKrasPtf1atm11creCvwPtf1aPtf1atm11creCvwPtf1aKrasKrastm4Tyj
• increased pancreas tumor incidence_Kras<tm4Tyj>/Kras<+>,Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0009153I129SSv129X1SvJC57BL6DBA2Krastm4TyjKrasTgfbr2tm12HlmTgfbr2tm12HlmPtf1atm11creCvwPtf1aKrasTgfbr2tm12HlmKrastm4TyjPtf1aPtf1atm11creCvw
• abnormal hepatic portal vein morphology_Kras<tm4Tyj>/Kras<+>,Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0010668I129SSv129X1SvJC57BL6DBA2Krastm4TyjKrasTgfbr2tm12HlmTgfbr2tm12HlmPtf1atm11creCvwPtf1aKrasTgfbr2tm12HlmKrastm4TyjPtf1aPtf1atm11creCvw
• hemorrhagic ascites_Kras<tm4Tyj>/Kras<+>,Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0013184I129SSv129X1SvJC57BL6DBA2Krastm4TyjKrasTgfbr2tm12HlmTgfbr2tm12HlmPtf1atm11creCvwPtf1aKrasTgfbr2tm12HlmKrastm4TyjPtf1aPtf1atm11creCvw
• weight loss_Kras<tm4Tyj>/Kras<+>,Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0001263I129SSv129X1SvJC57BL6DBA2Krastm4TyjKrasTgfbr2tm12HlmTgfbr2tm12HlmPtf1atm11creCvwPtf1aKrasTgfbr2tm12HlmKrastm4TyjPtf1aPtf1atm11creCvw
• premature death_Kras<tm4Tyj>/Kras<+>,Tgfbr2<tm1.2Hlm>/Tgfbr2<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0002083I129SSv129X1SvJC57BL6DBA2Krastm4TyjKrasTgfbr2tm12HlmTgfbr2Ptf1atm11creCvwPtf1aPtf1atm11creCvwKrasKrastm4TyjTgfbr2tm12HlmTgfbr2Ptf1a
• increased pancreatic intraepithelial neoplasia incidence_Kras<tm4Tyj>/Kras<+>,Tgfbr2<tm1.2Hlm>/Tgfbr2<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0009152I129SSv129X1SvJC57BL6DBA2Krastm4TyjKrasTgfbr2tm12HlmTgfbr2Ptf1atm11creCvwPtf1aPtf1atm11creCvwKrasKrastm4TyjTgfbr2tm12HlmTgfbr2Ptf1a
• increased pancreatic ductal adenocarcinoma incidence_Kras<tm4Tyj>/Kras<+>,Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0009151I129SSv129X1SvJC57BL6DBA2Krastm4TyjKrasTgfbr2tm12HlmTgfbr2tm12HlmPtf1atm11creCvwPtf1aKrasTgfbr2tm12HlmKrastm4TyjPtf1aPtf1atm11creCvw
• increased pancreatic ductal adenocarcinoma incidence_Kras<tm4Tyj>/Kras<+>,Tgfbr2<tm1.2Hlm>/Tgfbr2<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0009151I129SSv129X1SvJC57BL6DBA2Krastm4TyjKrasTgfbr2tm12HlmTgfbr2Ptf1atm11creCvwPtf1aPtf1atm11creCvwKrasKrastm4TyjTgfbr2tm12HlmTgfbr2Ptf1a
• increased metastatic potential_Kras<tm4Tyj>/Kras<+>,Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0001272I129SSv129X1SvJC57BL6DBA2Krastm4TyjKrasTgfbr2tm12HlmTgfbr2tm12HlmPtf1atm11creCvwPtf1aKrasTgfbr2tm12HlmKrastm4TyjPtf1aPtf1atm11creCvw
• distended abdomen_Kras<tm4Tyj>/Kras<+>,Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0001270I129SSv129X1SvJC57BL6DBA2Krastm4TyjKrasTgfbr2tm12HlmTgfbr2tm12HlmPtf1atm11creCvwPtf1aKrasTgfbr2tm12HlmKrastm4TyjPtf1aPtf1atm11creCvw
• dilated gallbladder_Kras<tm4Tyj>/Kras<+>,Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0009343I129SSv129X1SvJC57BL6DBA2Krastm4TyjKrasTgfbr2tm12HlmTgfbr2tm12HlmPtf1atm11creCvwPtf1aKrasTgfbr2tm12HlmKrastm4TyjPtf1aPtf1atm11creCvw
• premature death_Kras<tm4Tyj>/Kras<+>,Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0002083I129SSv129X1SvJC57BL6DBA2Krastm4TyjKrasTgfbr2tm12HlmTgfbr2tm12HlmPtf1atm11creCvwPtf1aKrasTgfbr2tm12HlmKrastm4TyjPtf1aPtf1atm11creCvw
• paralysis_Kras<tm4Tyj>/Kras<+>,Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0000753I129SSv129X1SvJC57BL6DBA2Krastm4TyjKrasTgfbr2tm12HlmTgfbr2tm12HlmPtf1atm11creCvwPtf1aKrasTgfbr2tm12HlmKrastm4TyjPtf1aPtf1atm11creCvw
• abnormal thrombosis_Kras<tm4Tyj>/Kras<+>,Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0005048I129SSv129X1SvJC57BL6DBA2Krastm4TyjKrasTgfbr2tm12HlmTgfbr2tm12HlmPtf1atm11creCvwPtf1aKrasTgfbr2tm12HlmKrastm4TyjPtf1aPtf1atm11creCvw