increased pancreas tumor incidence_Cdkn2a<tm2.1Rdp>/Cdkn2a<tm2.1Rdp>,Kras<tm4Tyj>/Kras<+>,Tg(Pdx1-cre)6Tuv/0

http://metadb.riken.jp/0009153I129S4SvJae129S6SvEvTacFVBNCdkn2atm21RdpCdkn2atm21RdpKrastm4TyjKrasTgPdx1cre6Tuv0KrasCdkn2atm21RdpTgPdx1cre6TuvKrastm4Tyj

increased pancreas tumor incidence_Cdkn2a<tm2.1Rdp>/Cdkn2a<tm2.1Rdp>,Kras<tm4Tyj>/Kras<+>,Tg(Pdx1-cre)6Tuv/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680
• transgene insertion 6, David A Tuveson
  http://metadb.riken.jp/db/mgi_rdf/MGI:5437123
• cyclin-dependent kinase inhibitor 2A
  http://metadb.riken.jp/db/mgi_rdf/MGI:104738

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cdkn2a<tm2.1Rdp>/Cdkn2a<tm2.1Rdp>,Kras<tm4Tyj>/Kras<+>,Tg(Pdx1-cre)6Tuv/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Kras<+>|Cdkn2a<tm2.1Rdp>|Tg(Pdx1-cre)6Tuv|Kras<tm4Tyj>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased pancreas tumor incidence
  http://purl.obolibrary.org/obo/MP_0009153

文献

http://purl.org/net/cito/citesAsAuthority

• Wanglong. Qiu, et.al., Disruption of p16 and activation of Kras in pancreas increase ductal adenocarcinoma formation and metastasis in vivo., Oncotarget, 2011, 2
  http://rdf.ncbi.nlm.nih.gov/pubmed/22113502