increased pancreas tumor incidence_Kras<tm4Tyj>/Kras<+>,Tgfbr2<tm1.2Hlm>/Tgfbr2<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>

http://metadb.riken.jp/0009153I129SSv129X1SvJC57BL6DBA2Krastm4TyjKrasTgfbr2tm12HlmTgfbr2Ptf1atm11creCvwPtf1aPtf1atm11creCvwKrasKrastm4TyjTgfbr2tm12HlmTgfbr2Ptf1a

increased pancreas tumor incidence_Kras<tm4Tyj>/Kras<+>,Tgfbr2<tm1.2Hlm>/Tgfbr2<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• pancreas specific transcription factor, 1a
  http://metadb.riken.jp/db/mgi_rdf/MGI:1328312
• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680
• transforming growth factor, beta receptor II
  http://metadb.riken.jp/db/mgi_rdf/MGI:98729

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Kras<tm4Tyj>/Kras<+>,Tgfbr2<tm1.2Hlm>/Tgfbr2<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Ptf1a<tm1.1(cre)Cvw>|Kras<+>|Kras<tm4Tyj>|Tgfbr2<tm1.2Hlm>|Tgfbr2<+>|Ptf1a<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased pancreas tumor incidence
  http://purl.obolibrary.org/obo/MP_0009153

文献

http://purl.org/net/cito/citesAsAuthority

• Hideaki. Ijichi, et.al., Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression., Genes & development, 2006, 20
  http://rdf.ncbi.nlm.nih.gov/pubmed/17114585