abnormal pancreatic beta cell differentiation_Nkx6-1<tm1Jlr>/Nkx6-1<tm1.1Msan>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Tg(Ins2-cre)25Mgn/0

http://metadb.riken.jp/0009175I129C57BL6DBASJLNkx61tm1JlrNkx61tm11MsanGtROSA26Sortm1EYFPCosGtROSA26SorTgIns2cre25Mgn0Nkx61tm1JlrGtROSA26Sortm1EYFPCosNkx61tm11MsanTgIns2cre25MgnGtROSA26Sor

abnormal pancreatic beta cell differentiation_Nkx6-1<tm1Jlr>/Nkx6-1<tm1.1Msan>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Tg(Ins2-cre)25Mgn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• NK6 homeobox 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1206039
• transgene insertion 25, Mark A Magnuson
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176225
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Nkx6-1<tm1Jlr>/Nkx6-1<tm1.1Msan>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Tg(Ins2-cre)25Mgn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Nkx6-1<tm1Jlr>|Gt(ROSA)26Sor<tm1(EYFP)Cos>|Nkx6-1<tm1.1Msan>|Tg(Ins2-cre)25Mgn|Gt(ROSA)26Sor<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * C57BL/6 * DBA * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal pancreatic beta cell differentiation
  http://purl.obolibrary.org/obo/MP_0009175

文献

http://purl.org/net/cito/citesAsAuthority

• Ashleigh E. Schaffer, et.al., Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity., PLoS genetics, 2013, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/23382704