abnormal pancreatic beta cell differentiation_Nkx2-2<tm2.1Suss>/Nkx2-2<tm2.1Suss>,Gt(ROSA)26Sor<tm14(CAG-tdTomato)Hze>/Gt(ROSA)26Sor<+>,Tg(Pdx1-cre/Esr1*)#Dam/0

http://metadb.riken.jp/0009175I129S6SvEvTacBlackSwissC57BL6CBASJLNkx22tm21SussNkx22tm21SussGtROSA26Sortm14CAGtdTomatoHzeGtROSA26SorTgPdx1creEsr1Dam0Nkx22tm21SussTgPdx1creEsr1DamGtROSA26Sortm14CAGtdTomatoHzeGtROSA26Sor

abnormal pancreatic beta cell differentiation_Nkx2-2<tm2.1Suss>/Nkx2-2<tm2.1Suss>,Gt(ROSA)26Sor<tm14(CAG-tdTomato)Hze>/Gt(ROSA)26Sor<+>,Tg(Pdx1-cre/Esr1*)#Dam/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• transgene insertion, Douglas A Melton
  http://metadb.riken.jp/db/mgi_rdf/MGI:5008262
• NK2 homeobox 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:97347

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Nkx2-2<tm2.1Suss>/Nkx2-2<tm2.1Suss>,Gt(ROSA)26Sor<tm14(CAG-tdTomato)Hze>/Gt(ROSA)26Sor<+>,Tg(Pdx1-cre/Esr1*)#Dam/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Nkx2-2<tm2.1Suss>|Tg(Pdx1-cre/Esr1*)#Dam|Gt(ROSA)26Sor<tm14(CAG-tdTomato)Hze>|Gt(ROSA)26Sor<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal pancreatic beta cell differentiation
  http://purl.obolibrary.org/obo/MP_0009175

文献

http://purl.org/net/cito/citesAsAuthority

• James B. Papizan, et.al., Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming., Genes & development, 2011, 25
  http://rdf.ncbi.nlm.nih.gov/pubmed/22056672