increased pancreatic alpha cell number_Gt(ROSA)26Sor<tm1(Kcnj11*V59M)Fmas>/Gt(ROSA)26Sor<+>,Tg(Ins2-cre)23Herr/0

http://metadb.riken.jp/0009176I129S4SvJaeC57BL6GtROSA26Sortm1Kcnj11V59MFmasGtROSA26SorTgIns2cre23Herr0GtROSA26SorTgIns2cre23HerrGtROSA26Sortm1Kcnj11V59MFmas

increased pancreatic alpha cell number_Gt(ROSA)26Sor<tm1(Kcnj11*V59M)Fmas>/Gt(ROSA)26Sor<+>,Tg(Ins2-cre)23Herr/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• transgene insertion 23, Pedro Luis Herrera
  http://metadb.riken.jp/db/mgi_rdf/MGI:4431238

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm1(Kcnj11*V59M)Fmas>/Gt(ROSA)26Sor<+>,Tg(Ins2-cre)23Herr/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gt(ROSA)26Sor<+>|Tg(Ins2-cre)23Herr|Gt(ROSA)26Sor<tm1(Kcnj11*V59M)Fmas>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased pancreatic alpha cell number
  http://purl.obolibrary.org/obo/MP_0009176

文献

http://purl.org/net/cito/citesAsAuthority

• Christophe A. Girard, et.al., Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes., The Journal of clinical investigation, 2009, 119
  http://rdf.ncbi.nlm.nih.gov/pubmed/19065048