Christophe A. Girard, et.al., Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes., The Journal of clinical investigation, 2009, 119

http://rdf.ncbi.nlm.nih.gov/pubmed/19065048

Christophe A. Girard, et.al., Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes., The Journal of clinical investigation, 2009, 119

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm1(Kcnj11*V59M)Fmas>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3832575

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal pancreatic beta cell physiology_Gt(ROSA)26Sor<tm1(Kcnj11*V59M)Fmas>/Gt(ROSA)26Sor<+>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0003562I129S4SvJaeC57BL6GtROSA26Sortm1Kcnj11V59MFmasGtROSA26SorTgIns2cre23Herr0GtROSA26SorTgIns2cre23HerrGtROSA26Sortm1Kcnj11V59MFmas
• polyuria_Gt(ROSA)26Sor<tm1(Kcnj11*V59M)Fmas>/Gt(ROSA)26Sor<+>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0001762I129S4SvJaeC57BL6GtROSA26Sortm1Kcnj11V59MFmasGtROSA26SorTgIns2cre23Herr0GtROSA26SorTgIns2cre23HerrGtROSA26Sortm1Kcnj11V59MFmas
• decreased insulin secretion_Gt(ROSA)26Sor<tm1(Kcnj11*V59M)Fmas>/Gt(ROSA)26Sor<+>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0003059I129S4SvJaeC57BL6GtROSA26Sortm1Kcnj11V59MFmasGtROSA26SorTgIns2cre23Herr0GtROSA26SorTgIns2cre23HerrGtROSA26Sortm1Kcnj11V59MFmas
• increased circulating glucose level_Gt(ROSA)26Sor<tm1(Kcnj11*V59M)Fmas>/Gt(ROSA)26Sor<+>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0005559I129S4SvJaeC57BL6GtROSA26Sortm1Kcnj11V59MFmasGtROSA26SorTgIns2cre23Herr0GtROSA26SorTgIns2cre23HerrGtROSA26Sortm1Kcnj11V59MFmas
• abnormal pancreatic beta cell morphology_Gt(ROSA)26Sor<tm1(Kcnj11*V59M)Fmas>/Gt(ROSA)26Sor<+>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0005217I129S4SvJaeC57BL6GtROSA26Sortm1Kcnj11V59MFmasGtROSA26SorTgIns2cre23Herr0GtROSA26SorTgIns2cre23HerrGtROSA26Sortm1Kcnj11V59MFmas
• decreased pancreatic beta cell number_Gt(ROSA)26Sor<tm1(Kcnj11*V59M)Fmas>/Gt(ROSA)26Sor<+>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0003339I129S4SvJaeC57BL6GtROSA26Sortm1Kcnj11V59MFmasGtROSA26SorTgIns2cre23Herr0GtROSA26SorTgIns2cre23HerrGtROSA26Sortm1Kcnj11V59MFmas
• decreased circulating insulin level_Gt(ROSA)26Sor<tm1(Kcnj11*V59M)Fmas>/Gt(ROSA)26Sor<+>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0002727I129S4SvJaeC57BL6GtROSA26Sortm1Kcnj11V59MFmasGtROSA26SorTgIns2cre23Herr0GtROSA26SorTgIns2cre23HerrGtROSA26Sortm1Kcnj11V59MFmas
• abnormal pancreatic islet morphology_Gt(ROSA)26Sor<tm1(Kcnj11*V59M)Fmas>/Gt(ROSA)26Sor<+>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0005215I129S4SvJaeC57BL6GtROSA26Sortm1Kcnj11V59MFmasGtROSA26SorTgIns2cre23Herr0GtROSA26SorTgIns2cre23HerrGtROSA26Sortm1Kcnj11V59MFmas
• increased circulating glucagon level_Gt(ROSA)26Sor<tm1(Kcnj11*V59M)Fmas>/Gt(ROSA)26Sor<+>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0002712I129S4SvJaeC57BL6GtROSA26Sortm1Kcnj11V59MFmasGtROSA26SorTgIns2cre23Herr0GtROSA26SorTgIns2cre23HerrGtROSA26Sortm1Kcnj11V59MFmas
• increased pancreatic alpha cell number_Gt(ROSA)26Sor<tm1(Kcnj11*V59M)Fmas>/Gt(ROSA)26Sor<+>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0009176I129S4SvJaeC57BL6GtROSA26Sortm1Kcnj11V59MFmasGtROSA26SorTgIns2cre23Herr0GtROSA26SorTgIns2cre23HerrGtROSA26Sortm1Kcnj11V59MFmas
• abnormal pancreatic alpha cell morphology_Gt(ROSA)26Sor<tm1(Kcnj11*V59M)Fmas>/Gt(ROSA)26Sor<+>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0005216I129S4SvJaeC57BL6GtROSA26Sortm1Kcnj11V59MFmasGtROSA26SorTgIns2cre23Herr0GtROSA26SorTgIns2cre23HerrGtROSA26Sortm1Kcnj11V59MFmas
• decreased body weight_Gt(ROSA)26Sor<tm1(Kcnj11*V59M)Fmas>/Gt(ROSA)26Sor<+>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0001262I129S4SvJaeC57BL6GtROSA26Sortm1Kcnj11V59MFmasGtROSA26SorTgIns2cre23Herr0GtROSA26SorTgIns2cre23HerrGtROSA26Sortm1Kcnj11V59MFmas

class

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm1(Kcnj11*V59M)Fmas>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3832575