abnormal pancreatic alpha cell differentiation_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Hprt<tm1(Ins2-HBEGF)Herr>/Y,Tg(Gcg-rtTA)#Herr/0,Tg(tetO-cre)1Jaw/0

http://metadb.riken.jp/0009179I129X1SvJC57BL6GtROSA26Sortm1EYFPCosGtROSA26SorHprttm1Ins2HBEGFHerrYTgGcgrtTAHerr0TgtetOcre1Jaw0TgtetOcre1JawGtROSA26SorGtROSA26Sortm1EYFPCosHprttm1Ins2HBEGFHerrTgGcgrtTAHerr

abnormal pancreatic alpha cell differentiation_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Hprt<tm1(Ins2-HBEGF)Herr>/Y,Tg(Gcg-rtTA)#Herr/0,Tg(tetO-cre)1Jaw/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• hypoxanthine guanine phosphoribosyl transferase
  http://metadb.riken.jp/db/mgi_rdf/MGI:96217
• transgene insertion 1, Jeffrey A Whitsett
  http://metadb.riken.jp/db/mgi_rdf/MGI:3028584
• transgene insertion, Pedro Luis Herrera
  http://metadb.riken.jp/db/mgi_rdf/MGI:5567825

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Hprt<tm1(Ins2-HBEGF)Herr>/Y,Tg(Gcg-rtTA)#Herr/0,Tg(tetO-cre)1Jaw/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(tetO-cre)1Jaw|Gt(ROSA)26Sor<+>|Gt(ROSA)26Sor<tm1(EYFP)Cos>|Hprt<tm1(Ins2-HBEGF)Herr>|Tg(Gcg-rtTA)#Herr

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129X1/SvJ * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal pancreatic alpha cell differentiation
  http://purl.obolibrary.org/obo/MP_0009179

文献

http://purl.org/net/cito/citesAsAuthority

• Fabrizio. Thorel, et.al., Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss., Nature, 2010, 464
  http://rdf.ncbi.nlm.nih.gov/pubmed/20364121