increased prostate intraepithelial neoplasia incidence_Braf<tm1Mmcm>/Braf<tm1Mmcm>,Nkx3-1<tm4(cre/ERT2)Mms>/Nkx3-1<+>,Pten<tm1Hwu>/Pten<+>

http://metadb.riken.jp/0009219I129P2OlaHsd129S4SvJae129S6SvEvTacC57BL6Braftm1MmcmBraftm1MmcmNkx31tm4creERT2MmsNkx31Ptentm1HwuPtenNkx31PtenPtentm1HwuNkx31tm4creERT2MmsBraftm1Mmcm

increased prostate intraepithelial neoplasia incidence_Braf<tm1Mmcm>/Braf<tm1Mmcm>,Nkx3-1<tm4(cre/ERT2)Mms>/Nkx3-1<+>,Pten<tm1Hwu>/Pten<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• NK-3 transcription factor, locus 1 (Drosophila)
  http://metadb.riken.jp/db/mgi_rdf/MGI:97352
• phosphatase and tensin homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:109583
• Braf transforming gene
  http://metadb.riken.jp/db/mgi_rdf/MGI:88190

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Braf<tm1Mmcm>/Braf<tm1Mmcm>,Nkx3-1<tm4(cre/ERT2)Mms>/Nkx3-1<+>,Pten<tm1Hwu>/Pten<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Nkx3-1<+>|Pten<+>|Pten<tm1Hwu>|Nkx3-1<tm4(cre/ERT2)Mms>|Braf<tm1Mmcm>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased prostate intraepithelial neoplasia incidence
  http://purl.obolibrary.org/obo/MP_0009219

文献

http://purl.org/net/cito/citesAsAuthority

• Jingqiang. Wang, et.al., B-Raf activation cooperates with PTEN loss to drive c-Myc expression in advanced prostate cancer., Cancer research, 2012, 72
  http://rdf.ncbi.nlm.nih.gov/pubmed/22836754