increased prostate intraepithelial neoplasia incidence_Pten<tm2.1Ppp>/Pten<tm2.1Ppp>,Tg(Pbsn-cre)4Prb/0

http://metadb.riken.jp/0009219I129S1SvC57BL6DBA2Ptentm21PppPtentm21PppTgPbsncre4Prb0Ptentm21PppTgPbsncre4Prb

increased prostate intraepithelial neoplasia incidence_Pten<tm2.1Ppp>/Pten<tm2.1Ppp>,Tg(Pbsn-cre)4Prb/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• phosphatase and tensin homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:109583
• transgene insertion 4, Pradip Roy-Burman
  http://metadb.riken.jp/db/mgi_rdf/MGI:2388169

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Pten<tm2.1Ppp>/Pten<tm2.1Ppp>,Tg(Pbsn-cre)4Prb/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Pten<tm2.1Ppp>|Tg(Pbsn-cre)4Prb

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * C57BL/6 * DBA/2

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased prostate intraepithelial neoplasia incidence
  http://purl.obolibrary.org/obo/MP_0009219

文献

http://purl.org/net/cito/citesAsAuthority

• Luc. Furic, et.al., eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression., Proceedings of the National Academy of Sciences of the United States of America, 2010, 107
  http://rdf.ncbi.nlm.nih.gov/pubmed/20679199
• Zhenbang. Chen, et.al., Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis., Nature, 2005, 436
  http://rdf.ncbi.nlm.nih.gov/pubmed/16079851
• Yu. Chen, et.al., ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss., Nature medicine, 2013, 19
  http://rdf.ncbi.nlm.nih.gov/pubmed/23817021