increased prostate intraepithelial neoplasia incidence_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Pbsn-cre)4Prb/0

http://metadb.riken.jp/0009219I129S4SvJaeC57BL6DBA2Ptentm1HwuPtentm1HwuTgPbsncre4Prb0Ptentm1HwuTgPbsncre4Prb

increased prostate intraepithelial neoplasia incidence_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Pbsn-cre)4Prb/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 4, Pradip Roy-Burman
  http://metadb.riken.jp/db/mgi_rdf/MGI:2388169
• phosphatase and tensin homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:109583

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Pbsn-cre)4Prb/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Pten<tm1Hwu>|Tg(Pbsn-cre)4Prb

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6 * DBA/2

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased prostate intraepithelial neoplasia incidence
  http://purl.obolibrary.org/obo/MP_0009219

文献

http://purl.org/net/cito/citesAsAuthority

• Olga. Klezovitch, et.al., A causal role for ERG in neoplastic transformation of prostate epithelium., Proceedings of the National Academy of Sciences of the United States of America, 2008, 105
  http://rdf.ncbi.nlm.nih.gov/pubmed/18245377
• David J. Mulholland, et.al., Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth., Cancer cell, 2011, 19
  http://rdf.ncbi.nlm.nih.gov/pubmed/21620777
• Esther. Baena, et.al., ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients., Genes & development, 2013, 27
  http://rdf.ncbi.nlm.nih.gov/pubmed/23512661