increased duodenum adenocarcinoma incidence_Cdh1<tm2Kem>/Cdh1<+>,Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pdx1-cre)6Tuv/0

http://metadb.riken.jp/0009311I129C57BL6FVBNCdh1tm2KemCdh1Smad4tm21CxdSmad4tm21CxdTrp53tm1BrnTrp53tm1BrnTgPdx1cre6Tuv0Smad4tm21CxdTgPdx1cre6TuvCdh1tm2KemCdh1Trp53tm1Brn

increased duodenum adenocarcinoma incidence_Cdh1<tm2Kem>/Cdh1<+>,Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pdx1-cre)6Tuv/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• cadherin 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:88354
• SMAD family member 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:894293
• transgene insertion 6, David A Tuveson
  http://metadb.riken.jp/db/mgi_rdf/MGI:5437123

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cdh1<tm2Kem>/Cdh1<+>,Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pdx1-cre)6Tuv/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Smad4<tm2.1Cxd>|Tg(Pdx1-cre)6Tuv|Cdh1<tm2Kem>|Cdh1<+>|Trp53<tm1Brn>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * C57BL/6 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased duodenum adenocarcinoma incidence
  http://purl.obolibrary.org/obo/MP_0009311

文献

http://purl.org/net/cito/citesAsAuthority

• Jun Won. Park, et.al., Cooperativity of E-cadherin and Smad4 loss to promote diffuse-type gastric adenocarcinoma and metastasis., Molecular cancer research : MCR, 2014, 12
  http://rdf.ncbi.nlm.nih.gov/pubmed/24784840