increased follicular lymphoma incidence_Kmt2d<tm1.1Kaig>/Kmt2d<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>,Tg(Vav-BCL2)1Jad/0

http://metadb.riken.jp/0009317I129P2OlaHsdC57BL6C57BL6JKmt2dtm11KaigKmt2dIghg1tm1creCgnIghg1TgVavBCL21Jad0TgVavBCL21JadIghg1tm1creCgnKmt2dKmt2dtm11KaigIghg1

increased follicular lymphoma incidence_Kmt2d<tm1.1Kaig>/Kmt2d<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>,Tg(Vav-BCL2)1Jad/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 1, Jerry M Adams
  http://metadb.riken.jp/db/mgi_rdf/MGI:3037069
• immunoglobulin heavy constant gamma 1 (G1m marker)
  http://metadb.riken.jp/db/mgi_rdf/MGI:96446
• lysine (K)-specific methyltransferase 2D
  http://metadb.riken.jp/db/mgi_rdf/MGI:2682319

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Kmt2d<tm1.1Kaig>/Kmt2d<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>,Tg(Vav-BCL2)1Jad/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Vav-BCL2)1Jad|Ighg1<tm1(cre)Cgn>|Kmt2d<+>|Kmt2d<tm1.1Kaig>|Ighg1<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased follicular lymphoma incidence
  http://purl.obolibrary.org/obo/MP_0009317

文献

http://purl.org/net/cito/citesAsAuthority

• Jiyuan. Zhang, et.al., Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis., Nature medicine, 2015, 21
  http://rdf.ncbi.nlm.nih.gov/pubmed/26366712