Jiyuan. Zhang, et.al., Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis., Nature medicine, 2015, 21

http://rdf.ncbi.nlm.nih.gov/pubmed/26366712

Jiyuan. Zhang, et.al., Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis., Nature medicine, 2015, 21

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• premature death_Tg(Vav-BCL2)1Jad/0
  http://metadb.riken.jp/0002083IC57BL6JTgVavBCL21Jad0TgVavBCL21Jad
• decreased IgG1 level_Kmt2d<tm1.1Kaig>/Kmt2d<tm1.1Kaig>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008495I129P2OlaHsdC57BL6Kmt2dtm11KaigKmt2dtm11KaigCd19tm1creCgnCd19Cd19Kmt2dtm11KaigCd19tm1creCgn
• increased B cell derived lymphoma incidence_Tg(Vav-BCL2)1Jad/0
  http://metadb.riken.jp/0002023IC57BL6JTgVavBCL21Jad0TgVavBCL21Jad
• increased B cell derived lymphoma incidence_Kmt2d<tm1.1Kaig>/Kmt2d<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>,Tg(Vav-BCL2)1Jad/0
  http://metadb.riken.jp/0002023I129P2OlaHsdC57BL6C57BL6JKmt2dtm11KaigKmt2dIghg1tm1creCgnIghg1TgVavBCL21Jad0TgVavBCL21JadIghg1tm1creCgnKmt2dKmt2dtm11KaigIghg1
• increased germinal center B cell number_Kmt2d<tm1.1Kaig>/Kmt2d<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008177I129P2OlaHsdC57BL6Kmt2dtm11KaigKmt2dCd19tm1creCgnCd19Kmt2dCd19tm1creCgnKmt2dtm11KaigCd19
• increased B cell proliferation_Kmt2d<tm1.1Kaig>/Kmt2d<tm1.1Kaig>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0005154I129P2OlaHsdC57BL6Kmt2dtm11KaigKmt2dtm11KaigCd19tm1creCgnCd19Cd19Kmt2dtm11KaigCd19tm1creCgn
• increased B cell derived lymphoma incidence_Kmt2d<tm1.1Kaig>/Kmt2d<tm1.1Kaig>,Ighg1<tm1(cre)Cgn>/Ighg1<+>,Tg(Vav-BCL2)1Jad/0
  http://metadb.riken.jp/0002023I129P2OlaHsdC57BL6C57BL6JKmt2dtm11KaigKmt2dtm11KaigIghg1tm1creCgnIghg1TgVavBCL21Jad0Ighg1tm1creCgnIghg1Kmt2dtm11KaigTgVavBCL21Jad
• increased germinal center B cell number_Kmt2d<tm1.1Kaig>/Kmt2d<tm1.1Kaig>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008177I129P2OlaHsdC57BL6Kmt2dtm11KaigKmt2dtm11KaigCd19tm1creCgnCd19Cd19Kmt2dtm11KaigCd19tm1creCgn
• premature death_Kmt2d<tm1.1Kaig>/Kmt2d<tm1.1Kaig>,Ighg1<tm1(cre)Cgn>/Ighg1<+>,Tg(Vav-BCL2)1Jad/0
  http://metadb.riken.jp/0002083I129P2OlaHsdC57BL6C57BL6JKmt2dtm11KaigKmt2dtm11KaigIghg1tm1creCgnIghg1TgVavBCL21Jad0Ighg1tm1creCgnIghg1Kmt2dtm11KaigTgVavBCL21Jad
• increased follicular lymphoma incidence_Tg(Vav-BCL2)1Jad/0
  http://metadb.riken.jp/0009317IC57BL6JTgVavBCL21Jad0TgVavBCL21Jad
• decreased IgM level_Kmt2d<tm1.1Kaig>/Kmt2d<tm1.1Kaig>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0001806I129P2OlaHsdC57BL6Kmt2dtm11KaigKmt2dtm11KaigCd19tm1creCgnCd19Cd19Kmt2dtm11KaigCd19tm1creCgn
• increased follicular lymphoma incidence_Kmt2d<tm1.1Kaig>/Kmt2d<tm1.1Kaig>,Ighg1<tm1(cre)Cgn>/Ighg1<+>,Tg(Vav-BCL2)1Jad/0
  http://metadb.riken.jp/0009317I129P2OlaHsdC57BL6C57BL6JKmt2dtm11KaigKmt2dtm11KaigIghg1tm1creCgnIghg1TgVavBCL21Jad0Ighg1tm1creCgnIghg1Kmt2dtm11KaigTgVavBCL21Jad
• increased follicular lymphoma incidence_Kmt2d<tm1.1Kaig>/Kmt2d<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>,Tg(Vav-BCL2)1Jad/0
  http://metadb.riken.jp/0009317I129P2OlaHsdC57BL6C57BL6JKmt2dtm11KaigKmt2dIghg1tm1creCgnIghg1TgVavBCL21Jad0TgVavBCL21JadIghg1tm1creCgnKmt2dKmt2dtm11KaigIghg1
• increased spleen germinal center size_Kmt2d<tm1.1Kaig>/Kmt2d<tm1.1Kaig>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008483I129P2OlaHsdC57BL6Kmt2dtm11KaigKmt2dtm11KaigCd19tm1creCgnCd19Cd19Kmt2dtm11KaigCd19tm1creCgn
• abnormal B cell differentiation_Kmt2d<tm1.1Kaig>/Kmt2d<tm1.1Kaig>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0002144I129P2OlaHsdC57BL6Kmt2dtm11KaigKmt2dtm11KaigCd19tm1creCgnCd19Cd19Kmt2dtm11KaigCd19tm1creCgn
• decreased B cell number_Kmt2d<tm1.1Kaig>/Kmt2d<tm1.1Kaig>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0005017I129P2OlaHsdC57BL6Kmt2dtm11KaigKmt2dtm11KaigCd19tm1creCgnCd19Cd19Kmt2dtm11KaigCd19tm1creCgn
• decreased mature B cell number_Kmt2d<tm1.1Kaig>/Kmt2d<tm1.1Kaig>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008211I129P2OlaHsdC57BL6Kmt2dtm11KaigKmt2dtm11KaigCd19tm1creCgnCd19Cd19Kmt2dtm11KaigCd19tm1creCgn
• increased spleen germinal center number_Kmt2d<tm1.1Kaig>/Kmt2d<tm1.1Kaig>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008481I129P2OlaHsdC57BL6Kmt2dtm11KaigKmt2dtm11KaigCd19tm1creCgnCd19Cd19Kmt2dtm11KaigCd19tm1creCgn
• increased spleen germinal center size_Kmt2d<tm1.1Kaig>/Kmt2d<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008483I129P2OlaHsdC57BL6Kmt2dtm11KaigKmt2dCd19tm1creCgnCd19Kmt2dCd19tm1creCgnKmt2dtm11KaigCd19
• decreased follicular B cell number_Kmt2d<tm1.1Kaig>/Kmt2d<tm1.1Kaig>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008174I129P2OlaHsdC57BL6Kmt2dtm11KaigKmt2dtm11KaigCd19tm1creCgnCd19Cd19Kmt2dtm11KaigCd19tm1creCgn
• premature death_Kmt2d<tm1.1Kaig>/Kmt2d<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>,Tg(Vav-BCL2)1Jad/0
  http://metadb.riken.jp/0002083I129P2OlaHsdC57BL6C57BL6JKmt2dtm11KaigKmt2dIghg1tm1creCgnIghg1TgVavBCL21Jad0TgVavBCL21JadIghg1tm1creCgnKmt2dKmt2dtm11KaigIghg1