increased lymphoblastic lymphoma incidence_Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Lck-cre)1Cwi/0

http://metadb.riken.jp/0009320I129S6SvEvTacC57BL6JPtpn11tm1CkqPtpn11TgLckcre1Cwi0Ptpn11Ptpn11tm1CkqTgLckcre1Cwi

increased lymphoblastic lymphoma incidence_Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Lck-cre)1Cwi/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• protein tyrosine phosphatase, non-receptor type 11
  http://metadb.riken.jp/db/mgi_rdf/MGI:99511
• transgene insertion 1, Christopher B Wilson
  http://metadb.riken.jp/db/mgi_rdf/MGI:2448687

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Lck-cre)1Cwi/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Ptpn11<+>|Ptpn11<tm1Ckq>|Tg(Lck-cre)1Cwi

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * C57BL/6J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased lymphoblastic lymphoma incidence
  http://purl.obolibrary.org/obo/MP_0009320

文献

http://purl.org/net/cito/citesAsAuthority

• Dan. Xu, et.al., Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells., The Journal of experimental medicine, 2011, 208
  http://rdf.ncbi.nlm.nih.gov/pubmed/21930766