abnormal chondrocyte physiology_Gt(ROSA)26Sor<tm5(ACTB-tTA)Luo>/Gt(ROSA)26Sor<+>,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0

http://metadb.riken.jp/0009780I129S1Sv129X1SvJC57BL6C57BL6JSJLGtROSA26Sortm5ACTBtTALuoGtROSA26SorTgCol2a1cre1Bhr0TgtetOCMVCol2a1R992CGFPAfe0TgtetOCMVCol2a1R992CGFPAfeTgCol2a1cre1BhrGtROSA26Sortm5ACTBtTALuoGtROSA26Sor

abnormal chondrocyte physiology_Gt(ROSA)26Sor<tm5(ACTB-tTA)Luo>/Gt(ROSA)26Sor<+>,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 1, Richard R Behringer
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176069
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• transgene insertion, Andrzej Fertala
  http://metadb.riken.jp/db/mgi_rdf/MGI:5643752

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm5(ACTB-tTA)Luo>/Gt(ROSA)26Sor<+>,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe|Tg(Col2a1-cre)1Bhr|Gt(ROSA)26Sor<tm5(ACTB-tTA)Luo>|Gt(ROSA)26Sor<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal chondrocyte physiology
  http://purl.obolibrary.org/obo/MP_0009780

文献

http://purl.org/net/cito/citesAsAuthority

• Machiko. Arita, et.al., Mechanisms of aberrant organization of growth plates in conditional transgenic mouse model of spondyloepiphyseal dysplasia associated with the R992C substitution in collagen II., The American journal of pathology, 2015, 185
  http://rdf.ncbi.nlm.nih.gov/pubmed/25451152