increased total body fat amount_Lepr<tm1Jke>/Lepr<tm1Jke>,Tg(Pomc1-cre)16Lowl/0

http://metadb.riken.jp/0010024I129X1SvJC57BL6JFVBNLeprtm1JkeLeprtm1JkeTgPomc1cre16Lowl0TgPomc1cre16LowlLeprtm1Jke

increased total body fat amount_Lepr<tm1Jke>/Lepr<tm1Jke>,Tg(Pomc1-cre)16Lowl/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• leptin receptor
  http://metadb.riken.jp/db/mgi_rdf/MGI:104993
• transgene insertion 16, Bradford B Lowell
  http://metadb.riken.jp/db/mgi_rdf/MGI:3640615

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Lepr<tm1Jke>/Lepr<tm1Jke>,Tg(Pomc1-cre)16Lowl/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Pomc1-cre)16Lowl|Lepr<tm1Jke>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129X1/SvJ * C57BL/6J * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased total body fat amount
  http://purl.obolibrary.org/obo/MP_0010024

文献

http://purl.org/net/cito/citesAsAuthority

• Eric D. Berglund, et.al., Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice., The Journal of clinical investigation, 2012, 122
  http://rdf.ncbi.nlm.nih.gov/pubmed/22326958