Eric D. Berglund, et.al., Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice., The Journal of clinical investigation, 2012, 122

http://rdf.ncbi.nlm.nih.gov/pubmed/22326958

Eric D. Berglund, et.al., Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice., The Journal of clinical investigation, 2012, 122

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Lepr<tm1Jke>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5426228

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• obese_Lepr<tm1Jke>/Lepr<tm1Jke>
  http://metadb.riken.jp/0001261I129X1SvJC57BL6JLeprtm1JkeLeprtm1JkeLeprtm1Jke
• decreased circulating glucose level_Lepr<tm1Jke>/Lepr<tm1Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0005560I129X1SvJC57BL6JFVBNLeprtm1JkeLeprtm1JkeTgPomc1cre16Lowl0TgPomc1cre16LowlLeprtm1Jke
• decreased total body fat amount_Lepr<tm1Jke>/Lepr<tm1Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0010025I129X1SvJC57BL6JFVBNLeprtm1JkeLeprtm1JkeTgPomc1cre16Lowl0TgPomc1cre16LowlLeprtm1Jke
• hypoactivity_Lepr<tm1Jke>/Lepr<tm1Jke>
  http://metadb.riken.jp/0001402I129X1SvJC57BL6JLeprtm1JkeLeprtm1JkeLeprtm1Jke
• decreased liver triglyceride level_Lepr<tm1Jke>/Lepr<tm1Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0009356I129X1SvJC57BL6JFVBNLeprtm1JkeLeprtm1JkeTgPomc1cre16Lowl0TgPomc1cre16LowlLeprtm1Jke
• decreased circulating triglyceride level_Lepr<tm1Jke>/Lepr<tm1Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0002644I129X1SvJC57BL6JFVBNLeprtm1JkeLeprtm1JkeTgPomc1cre16Lowl0TgPomc1cre16LowlLeprtm1Jke
• abnormal gluconeogenesis_Lepr<tm1Jke>/Lepr<tm1Jke>
  http://metadb.riken.jp/0003383I129X1SvJC57BL6JLeprtm1JkeLeprtm1JkeLeprtm1Jke
• increased insulin sensitivity_Lepr<tm1Jke>/Lepr<tm1Jke>
  http://metadb.riken.jp/0002891I129X1SvJC57BL6JLeprtm1JkeLeprtm1JkeLeprtm1Jke
• hyperglycemia_Lepr<tm1Jke>/Lepr<tm1Jke>
  http://metadb.riken.jp/0001559I129X1SvJC57BL6JLeprtm1JkeLeprtm1JkeLeprtm1Jke
• abnormal eating behavior_Lepr<tm1Jke>/Lepr<tm1Jke>
  http://metadb.riken.jp/0001431I129X1SvJC57BL6JLeprtm1JkeLeprtm1JkeLeprtm1Jke
• increased total body fat amount_Lepr<tm1Jke>/Lepr<tm1Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0010024I129X1SvJC57BL6JFVBNLeprtm1JkeLeprtm1JkeTgPomc1cre16Lowl0TgPomc1cre16LowlLeprtm1Jke
• decreased carbon dioxide production_Lepr<tm1Jke>/Lepr<tm1Jke>
  http://metadb.riken.jp/0008964I129X1SvJC57BL6JLeprtm1JkeLeprtm1JkeLeprtm1Jke
• increased circulating glucagon level_Lepr<tm1Jke>/Lepr<tm1Jke>
  http://metadb.riken.jp/0002712I129X1SvJC57BL6JLeprtm1JkeLeprtm1JkeLeprtm1Jke
• increased insulin secretion_Lepr<tm1Jke>/Lepr<tm1Jke>
  http://metadb.riken.jp/0003058I129X1SvJC57BL6JLeprtm1JkeLeprtm1JkeLeprtm1Jke
• obese_Lepr<tm1Jke>/Lepr<tm1Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0001261I129X1SvJC57BL6JFVBNLeprtm1JkeLeprtm1JkeTgPomc1cre16Lowl0TgPomc1cre16LowlLeprtm1Jke
• increased circulating cholesterol level_Lepr<tm1Jke>/Lepr<tm1Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0005178I129X1SvJC57BL6JFVBNLeprtm1JkeLeprtm1JkeTgPomc1cre16Lowl0TgPomc1cre16LowlLeprtm1Jke
• decreased oxygen consumption_Lepr<tm1Jke>/Lepr<tm1Jke>
  http://metadb.riken.jp/0005290I129X1SvJC57BL6JLeprtm1JkeLeprtm1JkeLeprtm1Jke
• increased circulating cholesterol level_Lepr<tm1Jke>/Lepr<tm1Jke>
  http://metadb.riken.jp/0005178I129X1SvJC57BL6JLeprtm1JkeLeprtm1JkeLeprtm1Jke
• decreased circulating cholesterol level_Lepr<tm1Jke>/Lepr<tm1Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0005179I129X1SvJC57BL6JFVBNLeprtm1JkeLeprtm1JkeTgPomc1cre16Lowl0TgPomc1cre16LowlLeprtm1Jke
• decreased respiratory quotient_Lepr<tm1Jke>/Lepr<tm1Jke>
  http://metadb.riken.jp/0010379I129X1SvJC57BL6JLeprtm1JkeLeprtm1JkeLeprtm1Jke
• increased respiratory quotient_Lepr<tm1Jke>/Lepr<tm1Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0010378I129X1SvJC57BL6JFVBNLeprtm1JkeLeprtm1JkeTgPomc1cre16Lowl0TgPomc1cre16LowlLeprtm1Jke
• abnormal glucose homeostasis_Lepr<tm1Jke>/Lepr<tm1Jke>
  http://metadb.riken.jp/0002078I129X1SvJC57BL6JLeprtm1JkeLeprtm1JkeLeprtm1Jke
• increased carbon dioxide production_Lepr<tm1Jke>/Lepr<tm1Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0008963I129X1SvJC57BL6JFVBNLeprtm1JkeLeprtm1JkeTgPomc1cre16Lowl0TgPomc1cre16LowlLeprtm1Jke
• increased circulating triglyceride level_Lepr<tm1Jke>/Lepr<tm1Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0001552I129X1SvJC57BL6JFVBNLeprtm1JkeLeprtm1JkeTgPomc1cre16Lowl0TgPomc1cre16LowlLeprtm1Jke
• increased insulin sensitivity_Lepr<tm1Jke>/Lepr<tm1Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0002891I129X1SvJC57BL6JFVBNLeprtm1JkeLeprtm1JkeTgPomc1cre16Lowl0TgPomc1cre16LowlLeprtm1Jke
• abnormal glucose homeostasis_Lepr<tm1Jke>/Lepr<tm1Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0002078I129X1SvJC57BL6JFVBNLeprtm1JkeLeprtm1JkeTgPomc1cre16Lowl0TgPomc1cre16LowlLeprtm1Jke
• increased circulating insulin level_Lepr<tm1Jke>/Lepr<tm1Jke>
  http://metadb.riken.jp/0002079I129X1SvJC57BL6JLeprtm1JkeLeprtm1JkeLeprtm1Jke
• increased circulating triglyceride level_Lepr<tm1Jke>/Lepr<tm1Jke>
  http://metadb.riken.jp/0001552I129X1SvJC57BL6JLeprtm1JkeLeprtm1JkeLeprtm1Jke
• decreased carbon dioxide production_Lepr<tm1Jke>/Lepr<tm1Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0008964I129X1SvJC57BL6JFVBNLeprtm1JkeLeprtm1JkeTgPomc1cre16Lowl0TgPomc1cre16LowlLeprtm1Jke
• increased circulating insulin level_Lepr<tm1Jke>/Lepr<tm1Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0002079I129X1SvJC57BL6JFVBNLeprtm1JkeLeprtm1JkeTgPomc1cre16Lowl0TgPomc1cre16LowlLeprtm1Jke
• increased liver triglyceride level_Lepr<tm1Jke>/Lepr<tm1Jke>
  http://metadb.riken.jp/0009355I129X1SvJC57BL6JLeprtm1JkeLeprtm1JkeLeprtm1Jke
• abnormal eating behavior_Lepr<tm1Jke>/Lepr<tm1Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0001431I129X1SvJC57BL6JFVBNLeprtm1JkeLeprtm1JkeTgPomc1cre16Lowl0TgPomc1cre16LowlLeprtm1Jke
• increased circulating leptin level_Lepr<tm1Jke>/Lepr<tm1Jke>
  http://metadb.riken.jp/0005669I129X1SvJC57BL6JLeprtm1JkeLeprtm1JkeLeprtm1Jke
• hyperactivity_Lepr<tm1Jke>/Lepr<tm1Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0001399I129X1SvJC57BL6JFVBNLeprtm1JkeLeprtm1JkeTgPomc1cre16Lowl0TgPomc1cre16LowlLeprtm1Jke
• increased liver triglyceride level_Lepr<tm1Jke>/Lepr<tm1Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0009355I129X1SvJC57BL6JFVBNLeprtm1JkeLeprtm1JkeTgPomc1cre16Lowl0TgPomc1cre16LowlLeprtm1Jke
• decreased circulating insulin level_Lepr<tm1Jke>/Lepr<tm1Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0002727I129X1SvJC57BL6JFVBNLeprtm1JkeLeprtm1JkeTgPomc1cre16Lowl0TgPomc1cre16LowlLeprtm1Jke
• increased insulin secretion_Lepr<tm1Jke>/Lepr<tm1Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0003058I129X1SvJC57BL6JFVBNLeprtm1JkeLeprtm1JkeTgPomc1cre16Lowl0TgPomc1cre16LowlLeprtm1Jke
• increased circulating leptin level_Lepr<tm1Jke>/Lepr<tm1Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0005669I129X1SvJC57BL6JFVBNLeprtm1JkeLeprtm1JkeTgPomc1cre16Lowl0TgPomc1cre16LowlLeprtm1Jke
• decreased body weight_Lepr<tm1Jke>/Lepr<tm1Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0001262I129X1SvJC57BL6JFVBNLeprtm1JkeLeprtm1JkeTgPomc1cre16Lowl0TgPomc1cre16LowlLeprtm1Jke
• decreased oxygen consumption_Lepr<tm1Jke>/Lepr<tm1Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0005290I129X1SvJC57BL6JFVBNLeprtm1JkeLeprtm1JkeTgPomc1cre16Lowl0TgPomc1cre16LowlLeprtm1Jke
• increased oxygen consumption_Lepr<tm1Jke>/Lepr<tm1Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0005289I129X1SvJC57BL6JFVBNLeprtm1JkeLeprtm1JkeTgPomc1cre16Lowl0TgPomc1cre16LowlLeprtm1Jke

class

http://purl.org/net/cito/citesAsAuthority

• Lepr<tm1Jke>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5426228