hypermyelination_Egr2<tm2(cre)Pch>/Egr2<+>,Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>/?,Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>

http://metadb.riken.jp/0010050I129P2OlaHsd129S2SvPasC57BL6Egr2tm2crePchEgr2GtROSA26Sortm8Map2k1EGFPRskyPtpn11tm11WbmPtpn11tm11WbmGtROSA26Sortm8Map2k1EGFPRskyEgr2Egr2tm2crePchPtpn11tm11Wbm

hypermyelination_Egr2<tm2(cre)Pch>/Egr2<+>,Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>/?,Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• early growth response 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:95296
• protein tyrosine phosphatase, non-receptor type 11
  http://metadb.riken.jp/db/mgi_rdf/MGI:99511

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Egr2<tm2(cre)Pch>/Egr2<+>,Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>/?,Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>|Egr2<+>|Egr2<tm2(cre)Pch>|Ptpn11<tm1.1Wbm>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• hypermyelination
  http://purl.obolibrary.org/obo/MP_0010050

文献

http://purl.org/net/cito/citesAsAuthority

• Maria E. Sheean, et.al., Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination., Genes & development, 2014, 28
  http://rdf.ncbi.nlm.nih.gov/pubmed/24493648