Maria E. Sheean, et.al., Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination., Genes & development, 2014, 28

http://rdf.ncbi.nlm.nih.gov/pubmed/24493648

Maria E. Sheean, et.al., Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination., Genes & development, 2014, 28

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal myelination_Erbb3<tm3Cbm>/Erbb3<tm3Cbm>,Gt(ROSA)26Sor<tm7(Pik3ca*,EGFP)Rsky>/?,Tg(Dhh-cre)1Mejr/0
  http://metadb.riken.jp/0000920I129P2OlaHsdC57BL6FVBNErbb3tm3CbmErbb3tm3CbmGtROSA26Sortm7Pik3caEGFPRskyTgDhhcre1Mejr0GtROSA26Sortm7Pik3caEGFPRskyTgDhhcre1MejrErbb3tm3Cbm
• abnormal myelination_Egr2<tm2(cre)Pch>/Egr2<+>,Gt(ROSA)26Sor<tm7(Pik3ca*,EGFP)Rsky>/?
  http://metadb.riken.jp/0000920I129S2SvPasC57BL6Egr2tm2crePchEgr2GtROSA26Sortm7Pik3caEGFPRskyEgr2Egr2tm2crePchGtROSA26Sortm7Pik3caEGFPRsky
• abnormal myelination_Erbb3<tm3Cbm>/Erbb3<tm3Cbm>,Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>/?,Tg(Dhh-cre)1Mejr/0
  http://metadb.riken.jp/0000920I129P2OlaHsdC57BL6FVBNErbb3tm3CbmErbb3tm3CbmGtROSA26Sortm8Map2k1EGFPRskyTgDhhcre1Mejr0GtROSA26Sortm8Map2k1EGFPRskyTgDhhcre1MejrErbb3tm3Cbm
• abnormal myelin sheath morphology_Egr2<tm2(cre)Pch>/Egr2<+>,Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>/?
  http://metadb.riken.jp/0003871I129S2SvPasC57BL6Egr2tm2crePchEgr2GtROSA26Sortm8Map2k1EGFPRskyEgr2tm2crePchEgr2GtROSA26Sortm8Map2k1EGFPRsky
• hypermyelination_Egr2<tm2(cre)Pch>/Egr2<+>,Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>/?,Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>
  http://metadb.riken.jp/0010050I129P2OlaHsd129S2SvPasC57BL6Egr2tm2crePchEgr2GtROSA26Sortm8Map2k1EGFPRskyPtpn11tm11WbmPtpn11tm11WbmGtROSA26Sortm8Map2k1EGFPRskyEgr2Egr2tm2crePchPtpn11tm11Wbm
• abnormal sciatic nerve morphology_Egr2<tm2(cre)Pch>/Egr2<+>,Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>/?
  http://metadb.riken.jp/0002651I129S2SvPasC57BL6Egr2tm2crePchEgr2GtROSA26Sortm8Map2k1EGFPRskyEgr2tm2crePchEgr2GtROSA26Sortm8Map2k1EGFPRsky
• abnormal Schwann cell physiology_Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>,Tg(Dhh-cre)1Mejr/0
  http://metadb.riken.jp/0011904I129P2OlaHsdFVBNPtpn11tm11WbmPtpn11tm11WbmTgDhhcre1Mejr0Ptpn11tm11WbmTgDhhcre1Mejr
• increased nerve conduction velocity_Egr2<tm2(cre)Pch>/Egr2<+>,Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>/?
  http://metadb.riken.jp/0011994I129S2SvPasC57BL6Egr2tm2crePchEgr2GtROSA26Sortm8Map2k1EGFPRskyEgr2tm2crePchEgr2GtROSA26Sortm8Map2k1EGFPRsky
• decreased myelin sheath thickness_Erbb3<tm3Cbm>/Erbb3<tm3Cbm>,Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>/?,Tg(Dhh-cre)1Mejr/0
  http://metadb.riken.jp/0011731I129P2OlaHsdC57BL6FVBNErbb3tm3CbmErbb3tm3CbmGtROSA26Sortm8Map2k1EGFPRskyTgDhhcre1Mejr0GtROSA26Sortm8Map2k1EGFPRskyTgDhhcre1MejrErbb3tm3Cbm
• abnormal nerve conduction_Egr2<tm2(cre)Pch>/Egr2<+>,Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>/?
  http://metadb.riken.jp/0005403I129S2SvPasC57BL6Egr2tm2crePchEgr2GtROSA26Sortm8Map2k1EGFPRskyEgr2tm2crePchEgr2GtROSA26Sortm8Map2k1EGFPRsky
• hypermyelination_Egr2<tm2(cre)Pch>/Egr2<+>,Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>/?
  http://metadb.riken.jp/0010050I129S2SvPasC57BL6Egr2tm2crePchEgr2GtROSA26Sortm8Map2k1EGFPRskyEgr2tm2crePchEgr2GtROSA26Sortm8Map2k1EGFPRsky
• tomacula_Egr2<tm2(cre)Pch>/Egr2<+>,Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>/?
  http://metadb.riken.jp/0012674I129S2SvPasC57BL6Egr2tm2crePchEgr2GtROSA26Sortm8Map2k1EGFPRskyEgr2tm2crePchEgr2GtROSA26Sortm8Map2k1EGFPRsky
• abnormal myelination_Gt(ROSA)26Sor<tm7(Pik3ca*,EGFP)Rsky>/?,Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>,Tg(Dhh-cre)1Mejr/0
  http://metadb.riken.jp/0000920I129P2OlaHsdC57BL6FVBNGtROSA26Sortm7Pik3caEGFPRskyPtpn11tm11WbmPtpn11tm11WbmTgDhhcre1Mejr0Ptpn11tm11WbmGtROSA26Sortm7Pik3caEGFPRskyTgDhhcre1Mejr
• increased myelin sheath thickness_Egr2<tm2(cre)Pch>/Egr2<+>,Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>/?
  http://metadb.riken.jp/0011730I129S2SvPasC57BL6Egr2tm2crePchEgr2GtROSA26Sortm8Map2k1EGFPRskyEgr2tm2crePchEgr2GtROSA26Sortm8Map2k1EGFPRsky
• abnormal myelination_Egr2<tm2(cre)Pch>/Egr2<+>,Gt(ROSA)26Sor<tm7(Pik3ca*,EGFP)Rsky>/?,Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>
  http://metadb.riken.jp/0000920I129P2OlaHsd129S2SvPasC57BL6Egr2tm2crePchEgr2GtROSA26Sortm7Pik3caEGFPRskyPtpn11tm11WbmPtpn11tm11WbmGtROSA26Sortm7Pik3caEGFPRskyEgr2Egr2tm2crePchPtpn11tm11Wbm
• absent Schwann cells_Erbb3<tm3Cbm>/Erbb3<tm3Cbm>,Tg(Dhh-cre)1Mejr/0
  http://metadb.riken.jp/0001108I129P2OlaHsdFVBNErbb3tm3CbmErbb3tm3CbmTgDhhcre1Mejr0Erbb3tm3CbmTgDhhcre1Mejr
• hypermyelination_Erbb3<tm3Cbm>/Erbb3<tm3Cbm>,Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>/?,Tg(Dhh-cre)1Mejr/0
  http://metadb.riken.jp/0010050I129P2OlaHsdC57BL6FVBNErbb3tm3CbmErbb3tm3CbmGtROSA26Sortm8Map2k1EGFPRskyTgDhhcre1Mejr0GtROSA26Sortm8Map2k1EGFPRskyTgDhhcre1MejrErbb3tm3Cbm
• decreased Schwann cell number_Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>,Tg(Dhh-cre)1Mejr/0
  http://metadb.riken.jp/0001107I129P2OlaHsdFVBNPtpn11tm11WbmPtpn11tm11WbmTgDhhcre1Mejr0Ptpn11tm11WbmTgDhhcre1Mejr
• hypermyelination_Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>/?,Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>,Tg(Dhh-cre)1Mejr/0
  http://metadb.riken.jp/0010050I129P2OlaHsdC57BL6FVBNGtROSA26Sortm8Map2k1EGFPRskyPtpn11tm11WbmPtpn11tm11WbmTgDhhcre1Mejr0TgDhhcre1MejrGtROSA26Sortm8Map2k1EGFPRskyPtpn11tm11Wbm
• abnormal myelination_Egr2<tm2(cre)Pch>/Egr2<+>,Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>
  http://metadb.riken.jp/0000920I129P2OlaHsd129S2SvPasC57BL6SJLEgr2tm2crePchEgr2Ptpn11tm11WbmPtpn11tm11WbmPtpn11tm11WbmEgr2tm2crePchEgr2