hypermyelination_Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>/?,Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>,Tg(Dhh-cre)1Mejr/0

http://metadb.riken.jp/0010050I129P2OlaHsdC57BL6FVBNGtROSA26Sortm8Map2k1EGFPRskyPtpn11tm11WbmPtpn11tm11WbmTgDhhcre1Mejr0TgDhhcre1MejrGtROSA26Sortm8Map2k1EGFPRskyPtpn11tm11Wbm

hypermyelination_Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>/?,Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>,Tg(Dhh-cre)1Mejr/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• transgene insertion 1, Dies Meijer
  http://metadb.riken.jp/db/mgi_rdf/MGI:4359596
• protein tyrosine phosphatase, non-receptor type 11
  http://metadb.riken.jp/db/mgi_rdf/MGI:99511

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>/?,Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>,Tg(Dhh-cre)1Mejr/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Dhh-cre)1Mejr|Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>|Ptpn11<tm1.1Wbm>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• hypermyelination
  http://purl.obolibrary.org/obo/MP_0010050

文献

http://purl.org/net/cito/citesAsAuthority

• Maria E. Sheean, et.al., Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination., Genes & development, 2014, 28
  http://rdf.ncbi.nlm.nih.gov/pubmed/24493648