increased melanoma incidence_Cdkn2a<tm2.1Nesh>/Cdkn2a<tm2.1Nesh>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Tyr-cre/ERT2)13Bos/0

http://metadb.riken.jp/0010275I129P2OlaHsdFVBCdkn2atm21NeshCdkn2atm21NeshTrp53tm1BrnTrp53tm1BrnTgTyrcreERT213Bos0Cdkn2atm21NeshTgTyrcreERT213BosTrp53tm1Brn

increased melanoma incidence_Cdkn2a<tm2.1Nesh>/Cdkn2a<tm2.1Nesh>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Tyr-cre/ERT2)13Bos/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• cyclin-dependent kinase inhibitor 2A
  http://metadb.riken.jp/db/mgi_rdf/MGI:104738
• transgene insertion 13, Marcus Bosenberg
  http://metadb.riken.jp/db/mgi_rdf/MGI:3641202
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cdkn2a<tm2.1Nesh>/Cdkn2a<tm2.1Nesh>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Tyr-cre/ERT2)13Bos/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Cdkn2a<tm2.1Nesh>|Tg(Tyr-cre/ERT2)13Bos|Trp53<tm1Brn>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * FVB

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased melanoma incidence
  http://purl.obolibrary.org/obo/MP_0010275

文献

http://purl.org/net/cito/citesAsAuthority

• K B. Monahan, et.al., Somatic p16(INK4a) loss accelerates melanomagenesis., Oncogene, 2010, 29
  http://rdf.ncbi.nlm.nih.gov/pubmed/20697345