K B. Monahan, et.al., Somatic p16(INK4a) loss accelerates melanomagenesis., Oncogene, 2010, 29

http://rdf.ncbi.nlm.nih.gov/pubmed/20697345

K B. Monahan, et.al., Somatic p16(INK4a) loss accelerates melanomagenesis., Oncogene, 2010, 29

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Cdkn2a<tm2.1Nesh>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4835008

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased melanoma incidence_Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0010275I129P2OlaHsd129S4SvJaeFVBKrastm4TyjKrasTrp53tm1BrnTrp53tm1BrnTgTyrcreERT213Bos0Trp53tm1BrnKrasKrastm4TyjTgTyrcreERT213Bos
• hyperpigmentation_Cdkn2a<tm2.1Nesh>/Cdkn2a<tm2.1Nesh>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0001188I129P2OlaHsdFVBCdkn2atm21NeshCdkn2atm21NeshTrp53tm1BrnTrp53tm1BrnTgTyrcreERT213Bos0Cdkn2atm21NeshTgTyrcreERT213BosTrp53tm1Brn
• increased spindle cell carcinoma incidence_Cdkn2a<tm2.1Nesh>/Cdkn2a<tm2.1Nesh>,Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0010367I129P2OlaHsd129S4SvJaeFVBCdkn2atm21NeshCdkn2atm21NeshKrastm4TyjKrasTrp53tm1BrnTrp53tm1BrnTgTyrcreERT213Bos0Cdkn2atm21NeshTgTyrcreERT213BosTrp53tm1BrnKrasKrastm4Tyj
• increased melanoma incidence_Kras<tm4Tyj>/Kras<+>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0010275I129S4SvJaeFVBKrastm4TyjKrasTgTyrcreERT213Bos0KrasKrastm4TyjTgTyrcreERT213Bos
• abnormal melanocyte morphology_Cdkn2a<tm2.1Nesh>/Cdkn2a<tm2.1Nesh>,Kras<tm4Tyj>/Kras<+>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0002877I129S4SvJaeFVBCdkn2atm21NeshCdkn2atm21NeshKrastm4TyjKrasTgTyrcreERT213Bos0Cdkn2atm21NeshTgTyrcreERT213BosKrastm4TyjKras
• hyperpigmentation_Cdkn2a<tm2.1Nesh>/Cdkn2a<+>,Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<+>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0001188I129P2OlaHsd129S4SvJaeFVBCdkn2atm21NeshCdkn2aKrastm4TyjKrasTrp53tm1BrnTrp53TgTyrcreERT213Bos0Krastm4TyjKrasTrp53tm1BrnTrp53TgTyrcreERT213BosCdkn2aCdkn2atm21Nesh
• increased melanoma incidence_Cdkn2a<tm2.1Nesh>/Cdkn2a<tm2.1Nesh>,Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0010275I129P2OlaHsd129S4SvJaeFVBCdkn2atm21NeshCdkn2atm21NeshKrastm4TyjKrasTrp53tm1BrnTrp53tm1BrnTgTyrcreERT213Bos0Cdkn2atm21NeshTgTyrcreERT213BosTrp53tm1BrnKrasKrastm4Tyj
• increased spindle cell carcinoma incidence_Cdkn2a<tm2.1Nesh>/Cdkn2a<tm2.1Nesh>,Kras<tm4Tyj>/Kras<+>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0010367I129S4SvJaeFVBCdkn2atm21NeshCdkn2atm21NeshKrastm4TyjKrasTgTyrcreERT213Bos0Cdkn2atm21NeshTgTyrcreERT213BosKrastm4TyjKras
• hyperpigmentation_Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0001188I129P2OlaHsd129S4SvJaeFVBKrastm4TyjKrasTrp53tm1BrnTrp53tm1BrnTgTyrcreERT213Bos0Trp53tm1BrnKrasKrastm4TyjTgTyrcreERT213Bos
• increased melanoma incidence_Cdkn2a<tm2.1Nesh>/Cdkn2a<tm2.1Nesh>,Kras<tm4Tyj>/Kras<+>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0010275I129S4SvJaeFVBCdkn2atm21NeshCdkn2atm21NeshKrastm4TyjKrasTgTyrcreERT213Bos0Cdkn2atm21NeshTgTyrcreERT213BosKrastm4TyjKras
• decreased tumor growth/size_Cdkn2a<tm1Rdp>/Cdkn2a<tm1Rdp>,X/Tg(Tyr-HRAS)60Lc
  http://metadb.riken.jp/0003447I129SvC57BL6JCBAJSJLCdkn2atm1RdpCdkn2atm1RdpXTgTyrHRAS60LcTgTyrHRAS60LcCdkn2atm1Rdp
• hyperpigmentation_Kras<tm4Tyj>/Kras<+>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0001188I129S4SvJaeFVBKrastm4TyjKrasTgTyrcreERT213Bos0KrasKrastm4TyjTgTyrcreERT213Bos
• abnormal melanocyte morphology_Cdkn2a<tm2.1Nesh>/Cdkn2a<tm2.1Nesh>,Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0002877I129P2OlaHsd129S4SvJaeFVBCdkn2atm21NeshCdkn2atm21NeshKrastm4TyjKrasTrp53tm1BrnTrp53tm1BrnTgTyrcreERT213Bos0Cdkn2atm21NeshTgTyrcreERT213BosTrp53tm1BrnKrasKrastm4Tyj
• increased spindle cell carcinoma incidence_Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0010367I129P2OlaHsd129S4SvJaeFVBKrastm4TyjKrasTrp53tm1BrnTrp53tm1BrnTgTyrcreERT213Bos0Trp53tm1BrnKrasKrastm4TyjTgTyrcreERT213Bos
• abnormal melanocyte morphology_Cdkn2a<tm2.1Nesh>/Cdkn2a<tm2.1Nesh>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0002877I129P2OlaHsdFVBCdkn2atm21NeshCdkn2atm21NeshTrp53tm1BrnTrp53tm1BrnTgTyrcreERT213Bos0Cdkn2atm21NeshTgTyrcreERT213BosTrp53tm1Brn
• increased tumor growth/size_Cdkn2a<tm2.1Nesh>/Cdkn2a<tm2.1Nesh>,Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0003721I129P2OlaHsd129S4SvJaeFVBCdkn2atm21NeshCdkn2atm21NeshKrastm4TyjKrasTrp53tm1BrnTrp53tm1BrnTgTyrcreERT213Bos0Cdkn2atm21NeshTgTyrcreERT213BosTrp53tm1BrnKrasKrastm4Tyj
• increased melanoma incidence_Cdkn2a<tm1Rdp>/Cdkn2a<tm1Rdp>,X/Tg(Tyr-HRAS)60Lc
  http://metadb.riken.jp/0010275I129SvC57BL6JCBAJSJLCdkn2atm1RdpCdkn2atm1RdpXTgTyrHRAS60LcTgTyrHRAS60LcCdkn2atm1Rdp
• abnormal melanocyte morphology_Cdkn2a<tm2.1Nesh>/Cdkn2a<+>,Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<+>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0002877I129P2OlaHsd129S4SvJaeFVBCdkn2atm21NeshCdkn2aKrastm4TyjKrasTrp53tm1BrnTrp53TgTyrcreERT213Bos0Krastm4TyjKrasTrp53tm1BrnTrp53TgTyrcreERT213BosCdkn2aCdkn2atm21Nesh
• increased melanoma incidence_Cdkn2a<tm2.1Nesh>/Cdkn2a<+>,Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<+>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0010275I129P2OlaHsd129S4SvJaeFVBCdkn2atm21NeshCdkn2aKrastm4TyjKrasTrp53tm1BrnTrp53TgTyrcreERT213Bos0Krastm4TyjKrasTrp53tm1BrnTrp53TgTyrcreERT213BosCdkn2aCdkn2atm21Nesh
• hyperpigmentation_Cdkn2a<tm2.1Nesh>/Cdkn2a<tm2.1Nesh>,Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0001188I129P2OlaHsd129S4SvJaeFVBCdkn2atm21NeshCdkn2atm21NeshKrastm4TyjKrasTrp53tm1BrnTrp53tm1BrnTgTyrcreERT213Bos0Cdkn2atm21NeshTgTyrcreERT213BosTrp53tm1BrnKrasKrastm4Tyj
• premature death_Cdkn2a<tm1Rdp>/Cdkn2a<tm1Rdp>,X/Tg(Tyr-HRAS)60Lc
  http://metadb.riken.jp/0002083I129SvC57BL6JCBAJSJLCdkn2atm1RdpCdkn2atm1RdpXTgTyrHRAS60LcTgTyrHRAS60LcCdkn2atm1Rdp
• abnormal melanocyte morphology_Kras<tm4Tyj>/Kras<+>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0002877I129S4SvJaeFVBKrastm4TyjKrasTgTyrcreERT213Bos0KrasKrastm4TyjTgTyrcreERT213Bos
• abnormal melanocyte morphology_Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0002877I129P2OlaHsd129S4SvJaeFVBKrastm4TyjKrasTrp53tm1BrnTrp53tm1BrnTgTyrcreERT213Bos0Trp53tm1BrnKrasKrastm4TyjTgTyrcreERT213Bos
• hyperpigmentation_Cdkn2a<tm2.1Nesh>/Cdkn2a<tm2.1Nesh>,Kras<tm4Tyj>/Kras<+>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0001188I129S4SvJaeFVBCdkn2atm21NeshCdkn2atm21NeshKrastm4TyjKrasTgTyrcreERT213Bos0Cdkn2atm21NeshTgTyrcreERT213BosKrastm4TyjKras
• premature death_Cdkn2a<tm2.1Nesh>/Cdkn2a<tm2.1Nesh>,Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0002083I129P2OlaHsd129S4SvJaeFVBCdkn2atm21NeshCdkn2atm21NeshKrastm4TyjKrasTrp53tm1BrnTrp53tm1BrnTgTyrcreERT213Bos0Cdkn2atm21NeshTgTyrcreERT213BosTrp53tm1BrnKrasKrastm4Tyj
• increased spindle cell carcinoma incidence_Cdkn2a<tm2.1Nesh>/Cdkn2a<+>,Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<+>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0010367I129P2OlaHsd129S4SvJaeFVBCdkn2atm21NeshCdkn2aKrastm4TyjKrasTrp53tm1BrnTrp53TgTyrcreERT213Bos0Krastm4TyjKrasTrp53tm1BrnTrp53TgTyrcreERT213BosCdkn2aCdkn2atm21Nesh
• increased melanoma incidence_Cdkn2a<tm2.1Nesh>/Cdkn2a<tm2.1Nesh>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0010275I129P2OlaHsdFVBCdkn2atm21NeshCdkn2atm21NeshTrp53tm1BrnTrp53tm1BrnTgTyrcreERT213Bos0Cdkn2atm21NeshTgTyrcreERT213BosTrp53tm1Brn

class

http://purl.org/net/cito/citesAsAuthority

• Cdkn2a<tm2.1Nesh>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4835008