increased melanoma incidence_Braf<tm1Rima>/Braf<+>,Tg(GFP/KRAS2/ALPP)1Brn/0,Tg(Tyr-cre/ERT2)1Lru/0

http://metadb.riken.jp/0010275IC57BL6DBA2FVBNBraftm1RimaBrafTgGFPKRAS2ALPP1Brn0TgTyrcreERT21Lru0BrafTgTyrcreERT21LruBraftm1RimaTgGFPKRAS2ALPP1Brn

increased melanoma incidence_Braf<tm1Rima>/Braf<+>,Tg(GFP/KRAS2/ALPP)1Brn/0,Tg(Tyr-cre/ERT2)1Lru/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• Braf transforming gene
  http://metadb.riken.jp/db/mgi_rdf/MGI:88190
• transgene insertion 1, Anton Berns
  http://metadb.riken.jp/db/mgi_rdf/MGI:3038964
• transgene insertion 1, Lionel Larue
  http://metadb.riken.jp/db/mgi_rdf/MGI:3617508

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Braf<tm1Rima>/Braf<+>,Tg(GFP/KRAS2/ALPP)1Brn/0,Tg(Tyr-cre/ERT2)1Lru/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Braf<+>|Tg(Tyr-cre/ERT2)1Lru|Braf<tm1Rima>|Tg(GFP/KRAS2/ALPP)1Brn

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: C57BL/6 * DBA/2 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased melanoma incidence
  http://purl.obolibrary.org/obo/MP_0010275

文献

http://purl.org/net/cito/citesAsAuthority

• Sonja J. Heidorn, et.al., Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF., Cell, 2010, 140
  http://rdf.ncbi.nlm.nih.gov/pubmed/20141835