increased hemolymphoid system tumor incidence_Pkn3<tm1.1Mrl>/Pkn3<tm1.1Mrl>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0

http://metadb.riken.jp/0010296I129S4SvJaeC57BL6CBAJPkn3tm11MrlPkn3tm11MrlPtentm1HwuPtentm1HwuTgMx1cre1Cgn0Ptentm1HwuPkn3tm11MrlTgMx1cre1Cgn

increased hemolymphoid system tumor incidence_Pkn3<tm1.1Mrl>/Pkn3<tm1.1Mrl>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• phosphatase and tensin homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:109583
• protein kinase N3
  http://metadb.riken.jp/db/mgi_rdf/MGI:2388285
• transgene insertion 1, University of Cologne
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176072

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Pkn3<tm1.1Mrl>/Pkn3<tm1.1Mrl>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Pten<tm1Hwu>|Pkn3<tm1.1Mrl>|Tg(Mx1-cre)1Cgn

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6 * CBA/J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased hemolymphoid system tumor incidence
  http://purl.obolibrary.org/obo/MP_0010296

文献

http://purl.org/net/cito/citesAsAuthority

• M. Kraus, et.al., Protein kinase N3 deficiency impedes PI3-kinase pathway-driven leukemogenesis without affecting normal hematopoiesis., Leukemia, 2015, 29
  http://rdf.ncbi.nlm.nih.gov/pubmed/25234167