increased skin tumor incidence_Brca1<tm1Brn>/Brca1<tm1Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT14-cre)8Brn/0

http://metadb.riken.jp/0010300I129P2OlaHsdC57BL6JFVBNBrca1tm1BrnBrca1tm1BrnTrp53tm1BrnTrp53tm1BrnTgKRT14cre8Brn0TgKRT14cre8BrnBrca1tm1BrnTrp53tm1Brn

increased skin tumor incidence_Brca1<tm1Brn>/Brca1<tm1Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT14-cre)8Brn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 8, Anton Berns
  http://metadb.riken.jp/db/mgi_rdf/MGI:2177242
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• breast cancer 1, early onset
  http://metadb.riken.jp/db/mgi_rdf/MGI:104537

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Brca1<tm1Brn>/Brca1<tm1Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT14-cre)8Brn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(KRT14-cre)8Brn|Brca1<tm1Brn>|Trp53<tm1Brn>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6J * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased skin tumor incidence
  http://purl.obolibrary.org/obo/MP_0010300

文献

http://purl.org/net/cito/citesAsAuthority

• Rinske. Drost, et.al., BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance., Cancer cell, 2011, 20
  http://rdf.ncbi.nlm.nih.gov/pubmed/22172724