Rinske. Drost, et.al., BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance., Cancer cell, 2011, 20

http://rdf.ncbi.nlm.nih.gov/pubmed/22172724

Rinske. Drost, et.al., BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance., Cancer cell, 2011, 20

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Brca1<tm1.1Jjon>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5307254

class

http://purl.org/net/cito/citesAsAuthority

• Brca1<tm1.1Jjon>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5307254

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased mammary gland tumor incidence_Brca1<tm1Brn>/Brca1<tm1Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT14-cre)8Brn/0
  http://metadb.riken.jp/0010299I129P2OlaHsdC57BL6JFVBNBrca1tm1BrnBrca1tm1BrnTrp53tm1BrnTrp53tm1BrnTgKRT14cre8Brn0TgKRT14cre8BrnBrca1tm1BrnTrp53tm1Brn
• increased skin tumor incidence_Brca1<tm1Brn>/Brca1<tm1Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT14-cre)8Brn/0
  http://metadb.riken.jp/0010300I129P2OlaHsdC57BL6JFVBNBrca1tm1BrnBrca1tm1BrnTrp53tm1BrnTrp53tm1BrnTgKRT14cre8Brn0TgKRT14cre8BrnBrca1tm1BrnTrp53tm1Brn
• altered tumor pathology_Brca1<tm1Brn>/Brca1<tm1.1Jjon>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT14-cre)8Brn/0
  http://metadb.riken.jp/0010639I129P2OlaHsdC57BL6JFVBNBrca1tm1BrnBrca1tm11JjonTrp53tm1BrnTrp53tm1BrnTgKRT14cre8Brn0Trp53tm1BrnBrca1tm11JjonTgKRT14cre8BrnBrca1tm1Brn
• abnormal tumor morphology_Brca1<tm1Brn>/Brca1<tm1.1Jjon>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT14-cre)8Brn/0
  http://metadb.riken.jp/0003448I129P2OlaHsdC57BL6JFVBNBrca1tm1BrnBrca1tm11JjonTrp53tm1BrnTrp53tm1BrnTgKRT14cre8Brn0Trp53tm1BrnBrca1tm11JjonTgKRT14cre8BrnBrca1tm1Brn
• embryonic growth retardation_Brca1<tm1.1Jjon>/Brca1<tm1.1Jjon>
  http://metadb.riken.jp/0003984IC57BL6JBrca1tm11JjonBrca1tm11JjonBrca1tm11Jjon
• decreased skin tumor incidence_Brca1<tm1Brn>/Brca1<tm1.1Jjon>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT14-cre)8Brn/0
  http://metadb.riken.jp/0010285I129P2OlaHsdC57BL6JFVBNBrca1tm1BrnBrca1tm11JjonTrp53tm1BrnTrp53tm1BrnTgKRT14cre8Brn0Trp53tm1BrnBrca1tm11JjonTgKRT14cre8BrnBrca1tm1Brn
• altered tumor pathology_Brca1<tm1Brn>/Brca1<tm1Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT14-cre)8Brn/0
  http://metadb.riken.jp/0010639I129P2OlaHsdC57BL6JFVBNBrca1tm1BrnBrca1tm1BrnTrp53tm1BrnTrp53tm1BrnTgKRT14cre8Brn0TgKRT14cre8BrnBrca1tm1BrnTrp53tm1Brn
• increased tumor latency_Brca1<tm1Brn>/Brca1<tm1Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT14-cre)8Brn/0
  http://metadb.riken.jp/0009828I129P2OlaHsdC57BL6JFVBNBrca1tm1BrnBrca1tm1BrnTrp53tm1BrnTrp53tm1BrnTgKRT14cre8Brn0TgKRT14cre8BrnBrca1tm1BrnTrp53tm1Brn
• decreased mammary gland tumor incidence_Brca1<tm1Brn>/Brca1<tm1.1Jjon>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT14-cre)8Brn/0
  http://metadb.riken.jp/0010269I129P2OlaHsdC57BL6JFVBNBrca1tm1BrnBrca1tm11JjonTrp53tm1BrnTrp53tm1BrnTgKRT14cre8Brn0Trp53tm1BrnBrca1tm11JjonTgKRT14cre8BrnBrca1tm1Brn
• embryonic lethality during organogenesis, complete penetrance_Brca1<tm1.1Jjon>/Brca1<tm1.1Jjon>
  http://metadb.riken.jp/0011098IC57BL6JBrca1tm11JjonBrca1tm11JjonBrca1tm11Jjon
• abnormal tumor morphology_Brca1<tm1Brn>/Brca1<tm1Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT14-cre)8Brn/0
  http://metadb.riken.jp/0003448I129P2OlaHsdC57BL6JFVBNBrca1tm1BrnBrca1tm1BrnTrp53tm1BrnTrp53tm1BrnTgKRT14cre8Brn0TgKRT14cre8BrnBrca1tm1BrnTrp53tm1Brn
• decreased tumor latency_Brca1<tm1Brn>/Brca1<tm1.1Jjon>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT14-cre)8Brn/0
  http://metadb.riken.jp/0010308I129P2OlaHsdC57BL6JFVBNBrca1tm1BrnBrca1tm11JjonTrp53tm1BrnTrp53tm1BrnTgKRT14cre8Brn0Trp53tm1BrnBrca1tm11JjonTgKRT14cre8BrnBrca1tm1Brn