decreased tumor latency_Palb2<tm1.1Dli>/Palb2<tm1.1Dli>,Trp53<tm1Brn>/Trp53<+>,Tg(KRT14-cre)1Amc/0

http://metadb.riken.jp/0010308I129P2OlaHsd129S4SvJaeSorC57BL6CBAPalb2tm11DliPalb2tm11DliTrp53tm1BrnTrp53TgKRT14cre1Amc0Trp53TgKRT14cre1AmcTrp53tm1BrnPalb2tm11Dli

decreased tumor latency_Palb2<tm1.1Dli>/Palb2<tm1.1Dli>,Trp53<tm1Brn>/Trp53<+>,Tg(KRT14-cre)1Amc/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• partner and localizer of BRCA2
  http://metadb.riken.jp/db/mgi_rdf/MGI:3040695
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• transgene insertion 1, Andrew P McMahon
  http://metadb.riken.jp/db/mgi_rdf/MGI:2450263

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Palb2<tm1.1Dli>/Palb2<tm1.1Dli>,Trp53<tm1Brn>/Trp53<+>,Tg(KRT14-cre)1Amc/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<+>|Tg(KRT14-cre)1Amc|Trp53<tm1Brn>|Palb2<tm1.1Dli>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased tumor latency
  http://purl.obolibrary.org/obo/MP_0010308

文献

http://purl.org/net/cito/citesAsAuthority

• Christian. Bowman-Colin, et.al., Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer., Proceedings of the National Academy of Sciences of the United States of America, 2013, 110
  http://rdf.ncbi.nlm.nih.gov/pubmed/23657012