Christian. Bowman-Colin, et.al., Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer., Proceedings of the National Academy of Sciences of the United States of America, 2013, 110

http://rdf.ncbi.nlm.nih.gov/pubmed/23657012

Christian. Bowman-Colin, et.al., Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer., Proceedings of the National Academy of Sciences of the United States of America, 2013, 110

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Palb2<tm1.1Dli>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5495825
• Palb2<tm1.2Dli>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5495930

class

http://purl.org/net/cito/citesAsAuthority

• Palb2<tm1.1Dli>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5495825
• Palb2<tm1.2Dli>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5495930

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal embryo development_Palb2<tm1.2Dli>/Palb2<tm1.2Dli>
  http://metadb.riken.jp/0001672I129S4SvJaeSorBALBcJC57BL6Palb2tm12DliPalb2tm12DliPalb2tm12Dli
• abnormal tumor morphology_Palb2<tm1.1Dli>/Palb2<tm1.1Dli>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT14-cre)1Amc/0
  http://metadb.riken.jp/0003448I129P2OlaHsd129S4SvJaeSorC57BL6CBAPalb2tm11DliPalb2tm11DliTrp53tm1BrnTrp53tm1BrnTgKRT14cre1Amc0Trp53tm1BrnTgKRT14cre1AmcPalb2tm11Dli
• exencephaly_Palb2<tm1.2Dli>/Palb2<tm1.2Dli>
  http://metadb.riken.jp/0000914I129S4SvJaeSorBALBcJC57BL6Palb2tm12DliPalb2tm12DliPalb2tm12Dli
• increased mouth tumor incidence_Palb2<tm1.1Dli>/Palb2<tm1.1Dli>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT14-cre)1Amc/0
  http://metadb.riken.jp/0003750I129P2OlaHsd129S4SvJaeSorC57BL6CBAPalb2tm11DliPalb2tm11DliTrp53tm1BrnTrp53tm1BrnTgKRT14cre1Amc0Trp53tm1BrnTgKRT14cre1AmcPalb2tm11Dli
• embryonic lethality, incomplete penetrance_Palb2<tm1.2Dli>/Palb2<tm1.2Dli>
  http://metadb.riken.jp/0011102I129S4SvJaeSorBALBcJC57BL6Palb2tm12DliPalb2tm12DliPalb2tm12Dli
• increased mammary gland tumor incidence_Palb2<tm1.1Dli>/Palb2<tm1.1Dli>,Trp53<tm1Brn>/Trp53<+>,Tg(KRT14-cre)1Amc/0
  http://metadb.riken.jp/0010299I129P2OlaHsd129S4SvJaeSorC57BL6CBAPalb2tm11DliPalb2tm11DliTrp53tm1BrnTrp53TgKRT14cre1Amc0Trp53TgKRT14cre1AmcTrp53tm1BrnPalb2tm11Dli
• decreased embryo size_Palb2<tm1.2Dli>/Palb2<tm1.2Dli>
  http://metadb.riken.jp/0001698I129S4SvJaeSorBALBcJC57BL6Palb2tm12DliPalb2tm12DliPalb2tm12Dli
• abnormal vitelline vasculature morphology_Palb2<tm1.2Dli>/Palb2<tm1.2Dli>
  http://metadb.riken.jp/0003229I129S4SvJaeSorBALBcJC57BL6Palb2tm12DliPalb2tm12DliPalb2tm12Dli
• increased skin tumor incidence_Palb2<tm1.1Dli>/Palb2<tm1.1Dli>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT14-cre)1Amc/0
  http://metadb.riken.jp/0010300I129P2OlaHsd129S4SvJaeSorC57BL6CBAPalb2tm11DliPalb2tm11DliTrp53tm1BrnTrp53tm1BrnTgKRT14cre1Amc0Trp53tm1BrnTgKRT14cre1AmcPalb2tm11Dli
• lethality throughout fetal growth and development, complete penetrance_Cdkn1a<tm1Tyj>/Cdkn1a<tm1Tyj>,Palb2<tm1.2Dli>/Palb2<tm1.2Dli>
  http://metadb.riken.jp/0011099I129S2SvPas129S4SvJaeSorBALBcJC57BL6Cdkn1atm1TyjCdkn1atm1TyjPalb2tm12DliPalb2tm12DliPalb2tm12DliCdkn1atm1Tyj
• abnormal embryo development_Cdkn1a<tm1Tyj>/Cdkn1a<tm1Tyj>,Palb2<tm1.2Dli>/Palb2<tm1.2Dli>
  http://metadb.riken.jp/0001672I129S2SvPas129S4SvJaeSorBALBcJC57BL6Cdkn1atm1TyjCdkn1atm1TyjPalb2tm12DliPalb2tm12DliPalb2tm12DliCdkn1atm1Tyj
• embryonic lethality during organogenesis, complete penetrance_Palb2<tm1.2Dli>/Palb2<tm1.2Dli>
  http://metadb.riken.jp/0011098I129S4SvJaeSorBALBcJC57BL6Palb2tm12DliPalb2tm12DliPalb2tm12Dli
• decreased tumor latency_Palb2<tm1.1Dli>/Palb2<tm1.1Dli>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT14-cre)1Amc/0
  http://metadb.riken.jp/0010308I129P2OlaHsd129S4SvJaeSorC57BL6CBAPalb2tm11DliPalb2tm11DliTrp53tm1BrnTrp53tm1BrnTgKRT14cre1Amc0Trp53tm1BrnTgKRT14cre1AmcPalb2tm11Dli
• chromosome breakage_Brca2<tm1Brn>/Brca2<tm1Brn>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0004028I129P2OlaHsdBrca2tm1BrnBrca2tm1BrnCd19tm1creCgnCd19Brca2tm1BrnCd19tm1creCgnCd19
• decreased tumor latency_Palb2<tm1.1Dli>/Palb2<tm1.1Dli>,Trp53<tm1Brn>/Trp53<+>,Tg(KRT14-cre)1Amc/0
  http://metadb.riken.jp/0010308I129P2OlaHsd129S4SvJaeSorC57BL6CBAPalb2tm11DliPalb2tm11DliTrp53tm1BrnTrp53TgKRT14cre1Amc0Trp53TgKRT14cre1AmcTrp53tm1BrnPalb2tm11Dli
• fetal growth retardation_Cdkn1a<tm1Tyj>/Cdkn1a<tm1Tyj>,Palb2<tm1.2Dli>/Palb2<tm1.2Dli>
  http://metadb.riken.jp/0004201I129S2SvPas129S4SvJaeSorBALBcJC57BL6Cdkn1atm1TyjCdkn1atm1TyjPalb2tm12DliPalb2tm12DliPalb2tm12DliCdkn1atm1Tyj
• chromosome breakage_Brca1<tm2Cxd>/Brca1<tm2Cxd>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0004028I129P2OlaHsd129S6SvEvTacBrca1tm2CxdBrca1tm2CxdCd19tm1creCgnCd19Cd19Brca1tm2CxdCd19tm1creCgn
• abnormal placental labyrinth vasculature morphology_Palb2<tm1.2Dli>/Palb2<tm1.2Dli>
  http://metadb.riken.jp/0008803I129S4SvJaeSorBALBcJC57BL6Palb2tm12DliPalb2tm12DliPalb2tm12Dli
• chromosome breakage_Brca2<tm1Brn>/Brca2<tm1Brn>,Trp53bp1<tm1Jc>/Trp53bp1<tm1Jc>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0004028I129P2OlaHsdBrca2tm1BrnBrca2tm1BrnTrp53bp1tm1JcTrp53bp1tm1JcCd19tm1creCgnCd19Cd19Brca2tm1BrnTrp53bp1tm1JcCd19tm1creCgn
• increased mammary gland tumor incidence_Palb2<tm1.1Dli>/Palb2<tm1.1Dli>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT14-cre)1Amc/0
  http://metadb.riken.jp/0010299I129P2OlaHsd129S4SvJaeSorC57BL6CBAPalb2tm11DliPalb2tm11DliTrp53tm1BrnTrp53tm1BrnTgKRT14cre1Amc0Trp53tm1BrnTgKRT14cre1AmcPalb2tm11Dli
• chromosome breakage_Palb2<tm1.1Dli>/Palb2<tm1.1Dli>,Trp53bp1<tm1Jc>/Trp53bp1<tm1Jc>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0004028I129P2OlaHsd129S4SvJaeSorC57BL6Palb2tm11DliPalb2tm11DliTrp53bp1tm1JcTrp53bp1tm1JcCd19tm1creCgnCd19Cd19tm1creCgnTrp53bp1tm1JcCd19Palb2tm11Dli