increased thyroid tumor incidence_Calca<tm1.1(cre/ERT2)Ptch>/Calca<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Rb1<tm2Brn>/Rb1<tm2Brn>

http://metadb.riken.jp/0010316I129129P2OlaHsdFVBNCalcatm11creERT2PtchCalcaTrp53tm1BrnTrp53tm1BrnRb1tm2BrnRb1tm2BrnRb1tm2BrnCalcaCalcatm11creERT2PtchTrp53tm1Brn

increased thyroid tumor incidence_Calca<tm1.1(cre/ERT2)Ptch>/Calca<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Rb1<tm2Brn>/Rb1<tm2Brn>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• RB transcriptional corepressor 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:97874
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• calcitonin/calcitonin-related polypeptide, alpha
  http://metadb.riken.jp/db/mgi_rdf/MGI:2151253

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Calca<tm1.1(cre/ERT2)Ptch>/Calca<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Rb1<tm2Brn>/Rb1<tm2Brn>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Rb1<tm2Brn>|Calca<+>|Calca<tm1.1(cre/ERT2)Ptch>|Trp53<tm1Brn>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * 129P2/OlaHsd * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased thyroid tumor incidence
  http://purl.obolibrary.org/obo/MP_0010316

文献

http://purl.org/net/cito/citesAsAuthority

• Hai. Song, et.al., Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis., Proceedings of the National Academy of Sciences of the United States of America, 2012, 109
  http://rdf.ncbi.nlm.nih.gov/pubmed/23047698