increased thyroid tumor incidence_Braf<tm1Cpri>/Braf<tm1Cpri>,Tshr<tm1Rmar>/Tshr<tm1Rmar>,Tg(TPO-cre)1Shk/0

http://metadb.riken.jp/0010316I129P2OlaHsd129S1SvFVBNCrBraftm1CpriBraftm1CpriTshrtm1RmarTshrtm1RmarTgTPOcre1Shk0Tshrtm1RmarBraftm1CpriTgTPOcre1Shk

increased thyroid tumor incidence_Braf<tm1Cpri>/Braf<tm1Cpri>,Tshr<tm1Rmar>/Tshr<tm1Rmar>,Tg(TPO-cre)1Shk/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• thyroid stimulating hormone receptor
  http://metadb.riken.jp/db/mgi_rdf/MGI:98849
• Braf transforming gene
  http://metadb.riken.jp/db/mgi_rdf/MGI:88190
• transgene insertion 1, Shioko Kimura
  http://metadb.riken.jp/db/mgi_rdf/MGI:3653643

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Braf<tm1Cpri>/Braf<tm1Cpri>,Tshr<tm1Rmar>/Tshr<tm1Rmar>,Tg(TPO-cre)1Shk/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tshr<tm1Rmar>|Braf<tm1Cpri>|Tg(TPO-cre)1Shk

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S1/Sv * FVB/NCr

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased thyroid tumor incidence
  http://purl.obolibrary.org/obo/MP_0010316

文献

http://purl.org/net/cito/citesAsAuthority

• Aime T. Franco, et.al., Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice., Proceedings of the National Academy of Sciences of the United States of America, 2011, 108
  http://rdf.ncbi.nlm.nih.gov/pubmed/21220306