Aime T. Franco, et.al., Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice., Proceedings of the National Academy of Sciences of the United States of America, 2011, 108

http://rdf.ncbi.nlm.nih.gov/pubmed/21220306

Aime T. Franco, et.al., Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice., Proceedings of the National Academy of Sciences of the United States of America, 2011, 108

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased activity of thyroid_Braf<tm1Cpri>/Braf<tm1Cpri>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0003503I129P2OlaHsdFVBNCrBraftm1CpriBraftm1CpriTgTPOcre1Shk0Braftm1CpriTgTPOcre1Shk
• increased thyroid tumor incidence_Braf<tm1Cpri>/Braf<tm1Cpri>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0010316I129P2OlaHsdFVBNCrBraftm1CpriBraftm1CpriTgTPOcre1Shk0Braftm1CpriTgTPOcre1Shk
• small thyroid gland_Tshr<tm1Rmar>/Tshr<tm1Rmar>
  http://metadb.riken.jp/0002951I129S1SvTshrtm1RmarTshrtm1RmarTshrtm1Rmar
• increased circulating thyroid-stimulating hormone level_Braf<tm1Cpri>/Braf<tm1Cpri>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0005122I129P2OlaHsdFVBNCrBraftm1CpriBraftm1CpriTgTPOcre1Shk0Braftm1CpriTgTPOcre1Shk
• abnormal thyroid follicle morphology_Tshr<tm1Rmar>/Tshr<tm1Rmar>
  http://metadb.riken.jp/0004696I129S1SvTshrtm1RmarTshrtm1RmarTshrtm1Rmar
• abnormal thyroid follicle morphology_Braf<tm1Cpri>/Braf<tm1Cpri>,Tshr<tm1Rmar>/Tshr<tm1Rmar>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0004696I129P2OlaHsd129S1SvFVBNCrBraftm1CpriBraftm1CpriTshrtm1RmarTshrtm1RmarTgTPOcre1Shk0Tshrtm1RmarBraftm1CpriTgTPOcre1Shk
• increased thyroid tumor incidence_Braf<tm1Cpri>/Braf<tm1Cpri>,Gnas<tm3Lsw>/Gnas<tm3Lsw>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0010316I129P2OlaHsd129S6SvEvTacFVBNCrBraftm1CpriBraftm1CpriGnastm3LswGnastm3LswTgTPOcre1Shk0Gnastm3LswTgTPOcre1ShkBraftm1Cpri
• increased thyroid tumor incidence_Braf<tm1Cpri>/Braf<tm1Cpri>,Tshr<tm1Rmar>/Tshr<tm1Rmar>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0010316I129P2OlaHsd129S1SvFVBNCrBraftm1CpriBraftm1CpriTshrtm1RmarTshrtm1RmarTgTPOcre1Shk0Tshrtm1RmarBraftm1CpriTgTPOcre1Shk
• increased circulating thyroxine level_Braf<tm1Cpri>/Braf<tm1Cpri>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0005477I129P2OlaHsdFVBNCrBraftm1CpriBraftm1CpriTgTPOcre1Shk0Braftm1CpriTgTPOcre1Shk
• decreased body weight_Braf<tm1Cpri>/Braf<tm1Cpri>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0001262I129P2OlaHsdFVBNCrBraftm1CpriBraftm1CpriTgTPOcre1Shk0Braftm1CpriTgTPOcre1Shk
• small thyroid gland_Braf<tm1Cpri>/Braf<tm1Cpri>,Tshr<tm1Rmar>/Tshr<tm1Rmar>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0002951I129P2OlaHsd129S1SvFVBNCrBraftm1CpriBraftm1CpriTshrtm1RmarTshrtm1RmarTgTPOcre1Shk0Tshrtm1RmarBraftm1CpriTgTPOcre1Shk
• increased thyroid carcinoma incidence_Braf<tm1Cpri>/Braf<tm1Cpri>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0010346I129P2OlaHsdFVBNCrBraftm1CpriBraftm1CpriTgTPOcre1Shk0Braftm1CpriTgTPOcre1Shk

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD03148
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD03148
• CD05690
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD05690
• CD28608
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD28608
• CD33801
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD33801