increased thyroid tumor incidence_Hras<tm1Jaf>/Hras<tm1Jaf>,Nf2<tm2Gth>/Nf2<tm2Gth>,Tg(TPO-cre)1Shk/0

http://metadb.riken.jp/0010316I129P2OlaHsd129S6SvEvTacBlackSwissC57BL6FVBNCrHrastm1JafHrastm1JafNf2tm2GthNf2tm2GthTgTPOcre1Shk0Nf2tm2GthHrastm1JafTgTPOcre1Shk

increased thyroid tumor incidence_Hras<tm1Jaf>/Hras<tm1Jaf>,Nf2<tm2Gth>/Nf2<tm2Gth>,Tg(TPO-cre)1Shk/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• neurofibromin 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:97307
• Harvey rat sarcoma virus oncogene
  http://metadb.riken.jp/db/mgi_rdf/MGI:96224
• transgene insertion 1, Shioko Kimura
  http://metadb.riken.jp/db/mgi_rdf/MGI:3653643

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Hras<tm1Jaf>/Hras<tm1Jaf>,Nf2<tm2Gth>/Nf2<tm2Gth>,Tg(TPO-cre)1Shk/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Nf2<tm2Gth>|Hras<tm1Jaf>|Tg(TPO-cre)1Shk

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * FVB/NCr

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased thyroid tumor incidence
  http://purl.obolibrary.org/obo/MP_0010316

文献

http://purl.org/net/cito/citesAsAuthority

• Maria E R. Garcia-Rendueles, et.al., NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition., Cancer discovery, 2015, 5
  http://rdf.ncbi.nlm.nih.gov/pubmed/26359368