Maria E R. Garcia-Rendueles, et.al., NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition., Cancer discovery, 2015, 5

http://rdf.ncbi.nlm.nih.gov/pubmed/26359368

Maria E R. Garcia-Rendueles, et.al., NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition., Cancer discovery, 2015, 5

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased thyroid tumor incidence_Hras<tm1Jaf>/Hras<tm1Jaf>,Pten<tm2.1Ppp>/Pten<tm2.1Ppp>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0010316I129S1Sv129S6SvEvTacFVBNCrHrastm1JafHrastm1JafPtentm21PppPtentm21PppTgTPOcre1Shk0Hrastm1JafTgTPOcre1ShkPtentm21Ppp
• increased thyroid tumor incidence_Hras<tm1Jaf>/Hras<tm1Jaf>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0010316I129P2OlaHsd129S6SvEvTacBlackSwissC57BL6FVBNCrHrastm1JafHrastm1JafTrp53tm1BrnTrp53tm1BrnTgTPOcre1Shk0Trp53tm1BrnHrastm1JafTgTPOcre1Shk
• abnormal thyroid gland morphology_Nf2<tm2Gth>/Nf2<tm2Gth>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0000681I129P2OlaHsdFVBNCrNf2tm2GthNf2tm2GthTgTPOcre1Shk0Nf2tm2GthTgTPOcre1Shk
• increased thyroid tumor incidence_Hras<tm1Jaf>/Hras<tm1Jaf>,Nf2<tm2Gth>/Nf2<tm2Gth>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0010316I129P2OlaHsd129S6SvEvTacBlackSwissC57BL6FVBNCrHrastm1JafHrastm1JafNf2tm2GthNf2tm2GthTgTPOcre1Shk0Nf2tm2GthHrastm1JafTgTPOcre1Shk

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal thyroid gland morphology in RBRC02344
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1015203
• neoplasm in RBRC02344
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1015689