increased thyroid tumor incidence_Braf<tm1Cpri>/Braf<tm1Cpri>,Gnas<tm3Lsw>/Gnas<tm3Lsw>,Tg(TPO-cre)1Shk/0

http://metadb.riken.jp/0010316I129P2OlaHsd129S6SvEvTacFVBNCrBraftm1CpriBraftm1CpriGnastm3LswGnastm3LswTgTPOcre1Shk0Gnastm3LswTgTPOcre1ShkBraftm1Cpri

increased thyroid tumor incidence_Braf<tm1Cpri>/Braf<tm1Cpri>,Gnas<tm3Lsw>/Gnas<tm3Lsw>,Tg(TPO-cre)1Shk/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
  http://metadb.riken.jp/db/mgi_rdf/MGI:95777
• transgene insertion 1, Shioko Kimura
  http://metadb.riken.jp/db/mgi_rdf/MGI:3653643
• Braf transforming gene
  http://metadb.riken.jp/db/mgi_rdf/MGI:88190

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Braf<tm1Cpri>/Braf<tm1Cpri>,Gnas<tm3Lsw>/Gnas<tm3Lsw>,Tg(TPO-cre)1Shk/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gnas<tm3Lsw>|Tg(TPO-cre)1Shk|Braf<tm1Cpri>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/NCr

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased thyroid tumor incidence
  http://purl.obolibrary.org/obo/MP_0010316

文献

http://purl.org/net/cito/citesAsAuthority

• Aime T. Franco, et.al., Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice., Proceedings of the National Academy of Sciences of the United States of America, 2011, 108
  http://rdf.ncbi.nlm.nih.gov/pubmed/21220306