increased cutaneous melanoma incidence_Cdkn2a<tm2.1Nesh>/Cdkn2a<tm2.1Nesh>,Nras<tm1.1Nesh>/Nras<tm1.1Nesh>,Stk11<tm1.1Rdp>/Stk11<tm1.1Rdp>,Tg(Tyr-cre/ERT2)13Bos/0

http://metadb.riken.jp/0010322B6JCgNrastm11NeshCdkn2atm21NeshStk11tm11RdpTgTyrcreERT213BosCdkn2atm21NeshCdkn2atm21NeshNrastm11NeshNrastm11NeshStk11tm11RdpStk11tm11RdpTgTyrcreERT213Bos0TgTyrcreERT213BosCdkn2atm21NeshNrastm11NeshStk11tm11Rdp

increased cutaneous melanoma incidence_Cdkn2a<tm2.1Nesh>/Cdkn2a<tm2.1Nesh>,Nras<tm1.1Nesh>/Nras<tm1.1Nesh>,Stk11<tm1.1Rdp>/Stk11<tm1.1Rdp>,Tg(Tyr-cre/ERT2)13Bos/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• serine/threonine kinase 11
  http://metadb.riken.jp/db/mgi_rdf/MGI:1341870
• neuroblastoma ras oncogene
  http://metadb.riken.jp/db/mgi_rdf/MGI:97376
• cyclin-dependent kinase inhibitor 2A
  http://metadb.riken.jp/db/mgi_rdf/MGI:104738
• transgene insertion 13, Marcus Bosenberg
  http://metadb.riken.jp/db/mgi_rdf/MGI:3641202

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cdkn2a<tm2.1Nesh>/Cdkn2a<tm2.1Nesh>,Nras<tm1.1Nesh>/Nras<tm1.1Nesh>,Stk11<tm1.1Rdp>/Stk11<tm1.1Rdp>,Tg(Tyr-cre/ERT2)13Bos/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Tyr-cre/ERT2)13Bos|Cdkn2a<tm2.1Nesh>|Nras<tm1.1Nesh>|Stk11<tm1.1Rdp>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• B6J.Cg-Nras<tm1.1Nesh> Cdkn2a<tm2.1Nesh> Stk11<tm1.1Rdp> Tg(Tyr-cre/ERT2)13Bos

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased cutaneous melanoma incidence
  http://purl.obolibrary.org/obo/MP_0010322

文献

http://purl.org/net/cito/citesAsAuthority

• Christin E. Burd, et.al., Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma., Cancer discovery, 2014, 4
  http://rdf.ncbi.nlm.nih.gov/pubmed/25252692