increased thyroid carcinoma incidence_Braf<tm1Mmcm>/Braf<+>,Trp53<tm3.1Tyj>/Trp53<+>,Tg(TPO-cre/ERT2)1139Tyj/0

http://metadb.riken.jp/0010346I129P2OlaHsd129S4SvJaeC57BL6C57BL6NTacBraftm1MmcmBrafTrp53tm31TyjTrp53TgTPOcreERT21139Tyj0Trp53tm31TyjBraftm1MmcmTgTPOcreERT21139TyjTrp53Braf

increased thyroid carcinoma incidence_Braf<tm1Mmcm>/Braf<+>,Trp53<tm3.1Tyj>/Trp53<+>,Tg(TPO-cre/ERT2)1139Tyj/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 1139, Tyler Jacks
  http://metadb.riken.jp/db/mgi_rdf/MGI:5565331
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• Braf transforming gene
  http://metadb.riken.jp/db/mgi_rdf/MGI:88190

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Braf<tm1Mmcm>/Braf<+>,Trp53<tm3.1Tyj>/Trp53<+>,Tg(TPO-cre/ERT2)1139Tyj/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<tm3.1Tyj>|Braf<tm1Mmcm>|Tg(TPO-cre/ERT2)1139Tyj|Trp53<+>|Braf<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased thyroid carcinoma incidence
  http://purl.obolibrary.org/obo/MP_0010346

文献

http://purl.org/net/cito/citesAsAuthority

• David G. McFadden, et.al., p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer., Proceedings of the National Academy of Sciences of the United States of America, 2014, 111
  http://rdf.ncbi.nlm.nih.gov/pubmed/24711431