David G. McFadden, et.al., p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer., Proceedings of the National Academy of Sciences of the United States of America, 2014, 111

http://rdf.ncbi.nlm.nih.gov/pubmed/24711431

David G. McFadden, et.al., p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer., Proceedings of the National Academy of Sciences of the United States of America, 2014, 111

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(TPO-cre/ERT2)1139Tyj
  http://metadb.riken.jp/db/mgi_rdf/MGI:5565332

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased metastatic potential_Braf<tm1Mmcm>/Braf<+>,Tg(TPO-cre/ERT2)1139Tyj/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0001272I129P2OlaHsd129S4SvJaeC57BL6C57BL6NTacBraftm1MmcmBrafTgTPOcreERT21139Tyj0Trp53tm1BrnTrp53tm1BrnBraftm1MmcmTgTPOcreERT21139TyjTrp53tm1BrnBraf
• respiratory failure_Braf<tm1Mmcm>/Braf<+>,Tg(TPO-cre/ERT2)1139Tyj/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0001953I129P2OlaHsd129S4SvJaeC57BL6C57BL6NTacBraftm1MmcmBrafTgTPOcreERT21139Tyj0Trp53tm1BrnTrp53tm1BrnBraftm1MmcmTgTPOcreERT21139TyjTrp53tm1BrnBraf
• increased thyroid carcinoma incidence_Braf<tm1Mmcm>/Braf<+>,Tg(TPO-cre/ERT2)1139Tyj/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0010346I129P2OlaHsd129S4SvJaeC57BL6C57BL6NTacBraftm1MmcmBrafTgTPOcreERT21139Tyj0Trp53tm1BrnTrp53tm1BrnBraftm1MmcmTgTPOcreERT21139TyjTrp53tm1BrnBraf
• increased thyroid carcinoma incidence_Braf<tm1Mmcm>/Braf<+>,Trp53<tm1Brn>/Trp53<tm3.1Tyj>,Tg(TPO-cre/ERT2)1139Tyj/0
  http://metadb.riken.jp/0010346I129P2OlaHsd129S4SvJaeC57BL6C57BL6NTacBraftm1MmcmBrafTrp53tm1BrnTrp53tm31TyjTgTPOcreERT21139Tyj0Trp53tm1BrnTrp53tm31TyjTgTPOcreERT21139TyjBraftm1MmcmBraf
• respiratory failure_Braf<tm1Mmcm>/Braf<+>,Tg(TPO-cre/ERT2)1139Tyj/0
  http://metadb.riken.jp/0001953I129P2OlaHsd129S4SvJaeC57BL6C57BL6NTacBraftm1MmcmBrafTgTPOcreERT21139Tyj0BrafTgTPOcreERT21139TyjBraftm1Mmcm
• increased thyroid-stimulating hormone level_Braf<tm1Mmcm>/Braf<+>,Tg(TPO-cre/ERT2)1139Tyj/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0005135I129P2OlaHsd129S4SvJaeC57BL6C57BL6NTacBraftm1MmcmBrafTgTPOcreERT21139Tyj0Trp53tm1BrnTrp53tm1BrnBraftm1MmcmTgTPOcreERT21139TyjTrp53tm1BrnBraf
• premature death_Braf<tm1Mmcm>/Braf<+>,Tg(TPO-cre/ERT2)1139Tyj/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0002083I129P2OlaHsd129S4SvJaeC57BL6C57BL6NTacBraftm1MmcmBrafTgTPOcreERT21139Tyj0Trp53tm1BrnTrp53tm1BrnBraftm1MmcmTgTPOcreERT21139TyjTrp53tm1BrnBraf
• increased thyroid carcinoma incidence_Braf<tm1Mmcm>/Braf<+>,Trp53<tm3.1Tyj>/Trp53<+>,Tg(TPO-cre/ERT2)1139Tyj/0
  http://metadb.riken.jp/0010346I129P2OlaHsd129S4SvJaeC57BL6C57BL6NTacBraftm1MmcmBrafTrp53tm31TyjTrp53TgTPOcreERT21139Tyj0Trp53tm31TyjBraftm1MmcmTgTPOcreERT21139TyjTrp53Braf
• increased thyroid carcinoma incidence_Braf<tm1Mmcm>/Braf<+>
  http://metadb.riken.jp/0010346I129P2OlaHsd129S4SvJaeC57BL6Braftm1MmcmBrafBrafBraftm1Mmcm
• increased thyroid carcinoma incidence_Braf<tm1Mmcm>/Braf<+>,Tg(TPO-cre/ERT2)1139Tyj/0
  http://metadb.riken.jp/0010346I129P2OlaHsd129S4SvJaeC57BL6C57BL6NTacBraftm1MmcmBrafTgTPOcreERT21139Tyj0BrafTgTPOcreERT21139TyjBraftm1Mmcm
• premature death_Braf<tm1Mmcm>/Braf<+>,Trp53<tm3.1Tyj>/Trp53<+>,Tg(TPO-cre/ERT2)1139Tyj/0
  http://metadb.riken.jp/0002083I129P2OlaHsd129S4SvJaeC57BL6C57BL6NTacBraftm1MmcmBrafTrp53tm31TyjTrp53TgTPOcreERT21139Tyj0Trp53tm31TyjBraftm1MmcmTgTPOcreERT21139TyjTrp53Braf

class

http://purl.org/net/cito/citesAsAuthority

• Tg(TPO-cre/ERT2)1139Tyj
  http://metadb.riken.jp/db/mgi_rdf/MGI:5565332