increased thyroid carcinoma incidence_Prkar1a<tm1.2Lsk>/Prkar1a<tm1.2Lsk>,Tg(TPO-cre)1Shk/0

http://metadb.riken.jp/0010346I129S1Sv129X1SvJFVBNCrPrkar1atm12LskPrkar1atm12LskTgTPOcre1Shk0Prkar1atm12LskTgTPOcre1Shk

increased thyroid carcinoma incidence_Prkar1a<tm1.2Lsk>/Prkar1a<tm1.2Lsk>,Tg(TPO-cre)1Shk/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 1, Shioko Kimura
  http://metadb.riken.jp/db/mgi_rdf/MGI:3653643
• protein kinase, cAMP dependent regulatory, type I, alpha
  http://metadb.riken.jp/db/mgi_rdf/MGI:104878

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Prkar1a<tm1.2Lsk>/Prkar1a<tm1.2Lsk>,Tg(TPO-cre)1Shk/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Prkar1a<tm1.2Lsk>|Tg(TPO-cre)1Shk

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased thyroid carcinoma incidence
  http://purl.obolibrary.org/obo/MP_0010346

文献

http://purl.org/net/cito/citesAsAuthority

• Daphne R. Pringle, et.al., Follicular thyroid cancers demonstrate dual activation of PKA and mTOR as modeled by thyroid-specific deletion of Prkar1a and Pten in mice., The Journal of clinical endocrinology and metabolism, 2014, 99
  http://rdf.ncbi.nlm.nih.gov/pubmed/24512487
• Daphne R. Pringle, et.al., Thyroid-specific ablation of the Carney complex gene, PRKAR1A, results in hyperthyroidism and follicular thyroid cancer., Endocrine-related cancer, 2012, 19
  http://rdf.ncbi.nlm.nih.gov/pubmed/22514108