increased pancreatic islet cell carcinoma incidence_Rb1<tm2Brn>/Rb1<tm2Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Ren-cre)#Kwg/0

http://metadb.riken.jp/0010348I129129P2OlaHsdRb1tm2BrnRb1tm2BrnTrp53tm1BrnTrp53tm1BrnTgRencreKwg0Rb1tm2BrnTrp53tm1BrnTgRencreKwg

increased pancreatic islet cell carcinoma incidence_Rb1<tm2Brn>/Rb1<tm2Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Ren-cre)#Kwg/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion, Kenneth W Gross
  http://metadb.riken.jp/db/mgi_rdf/MGI:5617968
• RB transcriptional corepressor 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:97874
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Rb1<tm2Brn>/Rb1<tm2Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Ren-cre)#Kwg/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Rb1<tm2Brn>|Trp53<tm1Brn>|Tg(Ren-cre)#Kwg

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * 129P2/OlaHsd

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased pancreatic islet cell carcinoma incidence
  http://purl.obolibrary.org/obo/MP_0010348

文献

http://purl.org/net/cito/citesAsAuthority

• S T. Glenn, et.al., Conditional deletion of p53 and Rb in the renin-expressing compartment of the pancreas leads to a highly penetrant metastatic pancreatic neuroendocrine carcinoma., Oncogene, 2014, 33
  http://rdf.ncbi.nlm.nih.gov/pubmed/24292676