S T. Glenn, et.al., Conditional deletion of p53 and Rb in the renin-expressing compartment of the pancreas leads to a highly penetrant metastatic pancreatic neuroendocrine carcinoma., Oncogene, 2014, 33

http://rdf.ncbi.nlm.nih.gov/pubmed/24292676

S T. Glenn, et.al., Conditional deletion of p53 and Rb in the renin-expressing compartment of the pancreas leads to a highly penetrant metastatic pancreatic neuroendocrine carcinoma., Oncogene, 2014, 33

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Ren-cre)#Kwg
  http://metadb.riken.jp/db/mgi_rdf/MGI:5617967

class

http://purl.org/net/cito/citesAsAuthority

• Tg(Ren-cre)#Kwg
  http://metadb.riken.jp/db/mgi_rdf/MGI:5617967

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased pancreatic islet cell carcinoma incidence_Rb1<tm2Brn>/Rb1<tm2Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Ren-cre)#Kwg/0
  http://metadb.riken.jp/0010348I129129P2OlaHsdRb1tm2BrnRb1tm2BrnTrp53tm1BrnTrp53tm1BrnTgRencreKwg0Rb1tm2BrnTrp53tm1BrnTgRencreKwg
• increased circulating glucagon level_Rb1<tm2Brn>/Rb1<tm2Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Ren-cre)#Kwg/0
  http://metadb.riken.jp/0002712I129129P2OlaHsdRb1tm2BrnRb1tm2BrnTrp53tm1BrnTrp53tm1BrnTgRencreKwg0Rb1tm2BrnTrp53tm1BrnTgRencreKwg
• increased metastatic potential_Rb1<tm2Brn>/Rb1<tm2Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Ren-cre)#Kwg/0
  http://metadb.riken.jp/0001272I129129P2OlaHsdRb1tm2BrnRb1tm2BrnTrp53tm1BrnTrp53tm1BrnTgRencreKwg0Rb1tm2BrnTrp53tm1BrnTgRencreKwg
• decreased body weight_Rb1<tm2Brn>/Rb1<tm2Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Ren-cre)#Kwg/0
  http://metadb.riken.jp/0001262I129129P2OlaHsdRb1tm2BrnRb1tm2BrnTrp53tm1BrnTrp53tm1BrnTgRencreKwg0Rb1tm2BrnTrp53tm1BrnTgRencreKwg
• increased glucagonoma incidence_Rb1<tm2Brn>/Rb1<tm2Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Ren-cre)#Kwg/0
  http://metadb.riken.jp/0003365I129129P2OlaHsdRb1tm2BrnRb1tm2BrnTrp53tm1BrnTrp53tm1BrnTgRencreKwg0Rb1tm2BrnTrp53tm1BrnTgRencreKwg
• premature death_Rb1<tm2Brn>/Rb1<tm2Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Ren-cre)#Kwg/0
  http://metadb.riken.jp/0002083I129129P2OlaHsdRb1tm2BrnRb1tm2BrnTrp53tm1BrnTrp53tm1BrnTgRencreKwg0Rb1tm2BrnTrp53tm1BrnTgRencreKwg
• increased sarcoma incidence_Rb1<tm2Brn>/Rb1<tm2Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Ren-cre)#Kwg/0
  http://metadb.riken.jp/0002032I129129P2OlaHsdRb1tm2BrnRb1tm2BrnTrp53tm1BrnTrp53tm1BrnTgRencreKwg0Rb1tm2BrnTrp53tm1BrnTgRencreKwg