increased spindle cell carcinoma incidence_Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<tm3Glo>,Tg(KRT5-cre/PGR)1Der/?

http://metadb.riken.jp/0010367I129Sv129P2OlaHsdC57BL6FVBICRKrastm4TyjKrasTrp53tm1BrnTrp53tm3GloTgKRT5crePGR1DerKrastm4TyjKrasTrp53tm3GloTgKRT5crePGR1DerTrp53tm1Brn

increased spindle cell carcinoma incidence_Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<tm3Glo>,Tg(KRT5-cre/PGR)1Der/?

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• transgene insertion 1, Dennis R Roop
  http://metadb.riken.jp/db/mgi_rdf/MGI:2651407

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<tm3Glo>,Tg(KRT5-cre/PGR)1Der/?

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Kras<tm4Tyj>|Kras<+>|Trp53<tm3Glo>|Tg(KRT5-cre/PGR)1Der|Trp53<tm1Brn>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * FVB * ICR

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased spindle cell carcinoma incidence
  http://purl.obolibrary.org/obo/MP_0010367

文献

http://purl.org/net/cito/citesAsAuthority

• Carlos. Caulin, et.al., An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations., The Journal of clinical investigation, 2007, 117
  http://rdf.ncbi.nlm.nih.gov/pubmed/17607363