myeloid hyperplasia_Ptpn11<tm1Ckq>/Ptpn11<+>,Lyz2<tm1(cre)Ifo>/Lyz2<+>

http://metadb.riken.jp/0010373I129P2OlaHsd129S6SvEvTacC57BL6JPtpn11tm1CkqPtpn11Lyz2tm1creIfoLyz2Ptpn11Lyz2tm1creIfoLyz2Ptpn11tm1Ckq

myeloid hyperplasia_Ptpn11<tm1Ckq>/Ptpn11<+>,Lyz2<tm1(cre)Ifo>/Lyz2<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• lysozyme 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:96897
• protein tyrosine phosphatase, non-receptor type 11
  http://metadb.riken.jp/db/mgi_rdf/MGI:99511

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Ptpn11<tm1Ckq>/Ptpn11<+>,Lyz2<tm1(cre)Ifo>/Lyz2<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Ptpn11<+>|Lyz2<tm1(cre)Ifo>|Lyz2<+>|Ptpn11<tm1Ckq>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• myeloid hyperplasia
  http://purl.obolibrary.org/obo/MP_0010373

文献

http://purl.org/net/cito/citesAsAuthority

• Dan. Xu, et.al., Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells., The Journal of experimental medicine, 2011, 208
  http://rdf.ncbi.nlm.nih.gov/pubmed/21930766